Matrix Metalloproteinase-2 Isoforms Differ within the Aortic Wall of Ascending Aortic Aneurysms Associated with Bicuspid Aortic Valve

Table 1

Patients’ characteristics.

Characteristics	Factor
Bicuspid aortic valve
Number of patients (% of study group)	N = 19 (45.2)
Age (years) (mean (SD))	57.38 (11.65)
Gender (%)
Female	N = 3 (15.8)
Male	N = 16 (84.2)
Ascending-aorta diameter (mm) (mean (SD))	51.42 (4.65)
Aortic valve function (%)
Normal/physiologic	N = 1 (5.2)
Stenosis	N = 3 (15.8)
Insufficiency	N = 4 (21.1)
Combined valve dysfunction	N = 11 (57.9)
Sievers classification (%) [7]
Type 0	N = 0 (0)
Type 1 L-R	N = 15 (79.0)
Type 1 L-N	N = 0 (0)
Type 1 R-N	N = 2 (10.5)
Type 2	N = 0 (0)
Not reliably classifiable	N = 2 (10.5)
Comorbidities
Hypertension (%)	N = 10 (52.6)
Hyperlipidemia (%)	N = 9 (47.4)
Diabetes mellitus (%)	N = 0 (0)
Connective tissue disorders (%)	N = 0 (0)
Tricuspid aortic valve
Number of patients (% of study group)	N = 23 (54.8)
Age (years) (mean (SD))	64.00 (14.50)
Gender (%)
Female	N = 7 (30.4)
Male	N = 16 (69.6)
Ascending-aorta diameter (mm) (mean (SD))	55.35 (8.41)
Aortic valve status (%)
Normal valve function	N = 3 (13.0)
Stenosis	N = 2 (8.7)
Insufficiency	N = 15 (65.3)
Combined valve dysfunction	N = 3 (13.0)
Comorbidities
Hypertension (%)	N = 15 (65.2)
Hyperlipidemia (%)	N = 10 (43.5)
Diabetes mellitus (%)	N = 3 (13.0)
Connective tissue disorders (%)	N = 2 (8.7)

SD: standard deviation; n = 1 Marfan syndrome and n = 1 alpha-actin-2 mutation.