Research Article
Matrix Metalloproteinase-2 Isoforms Differ within the Aortic Wall of Ascending Aortic Aneurysms Associated with Bicuspid Aortic Valve
Table 2
Results of zymography and ELISA (MMP-2 isoforms given in AU and MMP-14, TIMP-2, MMP-9, and TIMP-1 given in ng/ml).
| | Protein | Mean protein level (SD) BAV | TAV |
| | Pro-MMP-2 | | | | Anterior | 155.71 (56.63) | 155.25 (59.31) | | Posterior | 200.52 (37.54) | 167.00 (57.39) | | Averaged | 178.11 (34.73) | 161.12 (47.19) | | Active MMP-2 | | | | Anterior | 23.42 (10.05) | 28.98 (13.47) | | Posterior | 34.70 (18.89) | 35.25 (22.37) | | Averaged | 29.06 (8.81) | 32.12 (11.54) | | Total MMP-2 | | | | Anterior | 180.66 (53.64) | 185.11 (56.00) | | Posterior | 235.22 (48.69) | 202.25 (71.42) | | Averaged | 207.94 (41.05) | 193.68 (50.39) | | MMP-14 | | | | Anterior | 2.86 (0.93) | 3.61 (2.02) | | Posterior | 3.56 (1.59) | 4.06 (2.07) | | Averaged | 3.21 (0.95) | 3.84 (1.35) | | TIMP-2 | | | | Anterior | 18.72 (8.40) | 20.13 (9.45) | | Posterior | 26.90 (9.84) | 25.36 (12.78) | | Averaged | 22.81 (7.81) | 22.75 (8.31) | | MMP-9 | | | | Anterior | 14.56 (17.63) | 15.56 (19.93) | | Posterior | 17.60 (15.68) | 20.32 (33.24) | | Averaged | 16.08 (14.45) | 17.94 (24.98) | | TIMP-1 | | | | Anterior | 21.23 (14.01) | 35.30 (25.75) | | Posterior | 23.13 (15.86) | 34.82 (23.82) | | Averaged | 22.18 (13.52) | 35.06 (21.81) |
|
|
BAV: bicuspid aortic valve; TAV: tricuspid aortic valve; AU: arbitrary units; SD: standard deviation.
|
