Myocardial Scar on Surface ECG: Selvester Score, but Not Fragmentation, Predicts Response to CRT

Table 4

Selvester score and fragmented QRS univariable and multivariable analysis for the primary endpoint (response to CRT).

	Univariable binary logistic regression			Multivariable
	O.R.	95% C.I.	value	O.R.	95% C.I.	value
Age	1.005	0.975–1.037	0.727
Gender (female)	2.889	1.434–5.823	0.003	5.027	2.001–12.627	0.001
NYHA class	0.798	0.472–1.348	0.398
LVEF	0.943	0.891–0.997	0.039	0.864	0.801–0.933	<0.001
QRS (ms)	1.014	0.997–1.031	0.117
AF	0.242	0.088–0.666	0.006	0.199	0.064–0.621	0.005
Etiology (ischemic)	0.790	0.424–1.473	0.458
Hypertension	0.998	0.485–2.053	0.996
Diabetes mellitus	0.455	0.230–0.899	0.023	0.331	0.143–0.765	0.010
Dyslipidemia	0.802	0.432–1.491	0.486
ACE-is/ARBs	1.565	0.589–4.158	0.369
Beta-blockers	1.778	0.844–3.345	0.130
Statins	0.751	0.407–1.386	0.360
MRAs	1.220	0.666–2.237	0.520
Diuretics	0.668	0.283–1.575	0.357
Selvester score	0.869	0.809–0.934	<0.001
Selvester score ≥7	0.335	0.179–0.627	0.001	0.327	0.155–0.689	0.003
Fragmented QRS	0.793	0.431–1.461	0.457	1.133	0.539–2.381	0.742
LVEDD (mm)	0.976	0.939–1.016	0.976
LVESD (mm)	0.991	0.955–1.028	0.635
LVEDV (mL)	1.005	0.999–1.012	0.127
LVESV (mL)	1.006	0.998–1.014	0.134

Model 1 includes Selvester score ≥7. In model 2, Selvester score is expressed as continuous variable; OR 0.884 (0.813–0.960); : 0.004. Gender (female), LVEF, AF, diabetes mellitus, and fragmented QRS showed the same OR and values as in model 1. AF, atrial fibrillation; NYHA, New York Heart Association; LVEF, left ventricular ejection fraction; ACE-I, angiotensin converting enzyme-inhibitors; ARBs, angiotensin receptor blockers; MRAs, mineralocorticoid receptor antagonists; LVEDD, left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; LVEDV, left ventricular end-diastolic volume; and LVESV, left ventricular end-systolic volume.