Review Article

The Association of New-Onset Atrial Fibrillation and Risk of Cancer: A Systematic Review and Meta-Analysis

Table 1

The characteristics of studies included in the meta-analysis.

StudyDesignLocationParticipantsTotal, NExcludedPeriod of enrollmentFollow-up duration (median)Covariates in an adjusted modelNOS score

Conen 2016 [9]Prospective cohort studyUSAFemale health professionals (>45)34691Prior AF/CA/CVD1993–201319.1 (17.6–19.7)Age, BMI, HTN, DM, smoke, race, and comorbidity9

Wassertheil 2017 [10]Prospective cohort studyUSAPostmenopausal women (50–79)86046NAFrom 199415.9Age, race, parity, age at first birth, and cancer-specific potential confounders8

Hung 2018 [11]Retrospective cohort studyTaipei, ChinaIndividual from 20055130<20Y Prior AF/CA2005–20103.4 ± 2NA8

Saliba 2018 [12]Prospective case-control studiesUSA and IsraelNA19991NAFrom 1998>3YAge, sex, smoking, alcohol consumption, education, medication use, and comorbidity8

Vinter 2018 [13]Prospective cohort studyDenmarkNA55101Nonmelanoma skin cancer1993–201319.7Age, BMI, smoking duration, and alcohol consumption,7

Hung 2019 [14]Prospective cohort studyTaipei, ChinaNA332555<20Y Prior CA1996–20113.1 (0.97–6.53)Age, sex, risk factors, and comorbidity8

AF, atrial fibrillation; CA, cancer; CVD, cardiovascular disease; BMI, body mass index; HTN, hypertension; DM, diabetes mellitus; NA, not applicable; NOS, Newcastle–Ottawa Quality Assessment Scale.