The Association of New-Onset Atrial Fibrillation and Risk of Cancer: A Systematic Review and Meta-Analysis

Table 3

The subgroup analysis of the association between AF and CA..

Study	Subgroup	Number of studies	RR	Meta-analysis		Heterogeneity I^2 (%)	Test for subgroup differences I^2 (%)
				95% CI	value
Gender	Male	3	1.39	1.33, 1.45	<0.00001	21	44.7
	Female	3	1.26	1.11, 1.44	0.0005	78
Subtype of cancer	Colorectal cancer	6	1.22	0.92, 1.60	0.16	92	87.9
	Lung cancer	4	1.51	1.47, 1.55	<0.00001	0
	Breast cancer	5	1.10	0.94, 1.29	0.25	80
Time interval between CA diagnosis and AF	＜3M	4	3.44	2.29, 5.17	<0.00001	88	92.9
	3–12M	4	1.38	0.90, 2.12	0.14	97
	＞12M	4	1.09	0.95, 1.24	0.24	92

AF, atrial fibrillation; CA, cancer; RR, risk ratio.