|
| Author | Year | Disease | Reprogramming | Typical colony | UiPSCs pluripotency | Cardiomyocyte induction | Functional cardiomyocytes |
| Efficiency | Spontaneously contractive | Reference |
|
| Guan et al. | 2013 | Duchenne muscular dystrophy | A polycistronic lentiviral vector Oct-3/4, Sox2, Klf4, and c-Myc | 10–14 days | Teratoma with all 3 germ layers | Activin/BMP method | 80% | After 8–20 days of differentiation | [29] |
| Jouni et al. | 2015 | Type 2 long QT syndrome | Episomal vectors OCT3/4, SOX2, KLF4, MYC, LIN28, NANOG, SV40LT | | Teratoma with all 3 germ layers | Matrix sandwich method | — | After 6–8 days of differentiation | [50] |
| Lin et al. | 2016 | Dilated cardiomyopathy | Sendai virus OCT3/4, Sox2, Klf4, and c-Myc | — | Teratoma with all 3 germ layers | — | — | — | [51] |
| Cao et al. | 2018 | Ventricular septal defect | Sendai virus sOct4/Sox2, c-Myc, Klf4 | Around 3–4 weeks | Teratoma with all 3 germ layers | Small-molecule modulation of Wnt signaling | 75–80% | After 12 days of differentiation | [41] |
|
