Cardiology Research and Practice / 2020 / Article / Fig 5

Research Article

Aliskiren Improved the Endothelial Repair Capacity of Endothelial Progenitor Cells from Patients with Hypertension via the Tie2/PI3k/Akt/eNOS Signalling Pathway

Figure 5

The role of the Tie2/PI3k/AKT pathway in the aliskiren-induced phosphorylation of eNOS. (a) Quantification analysis of aliskiren-induced Akt phosphorylation in EPCs with Tie2 knockdown or after PI3k inhibition (LY294002) ( vs. non-aliskiren-treated EPCs from normotensive subjects, n = 18 per group; vs. aliskiren-treated EPCs from hypertensive patients, n = 18 per group). (b) Quantification analysis of aliskiren-induced eNOS phosphorylation in EPCs with Tie2 knockdown or after PI3k or eNOS inhibition (LY-NAME) ( vs. non-aliskiren-treated EPCs from normotensive subjects, n = 18 per group; vs. aliskiren-treated EPCs from hypertensive patients, n = 18 per group).
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