The Mechanism and Management of Adverse Cardiac Reactions Induced by Immune Checkpoint Inhibitors Therapy

Table 2

Immunomodulatory drugs and mechanism of action [31].

Drug	Main mechanism of action
Steroid	By inhibiting interleukin transcription, reducing cytokine synthesis, inhibiting neutrophil apoptosis, and reducing macrophage function, it has multiple effects on T cells, B cells, and phagocytic cells
Infliximab	Antibody that inhibits the binding of inflammatory cytokine tumor necrosis factor alpha (TNF-a) to its receptor
Mycophenolate mofetil	Inhibition of inosine monophosphate dehydrogenase (IMPDH) and inosine monophosphate dehydrogenase
Tacrolimus and cyclosporine	Calcineurin inhibitors can limit the transcription of interleukin 2 (IL-2) and participate in T-cell proliferation