Diagnostic Role of Plasma MicroRNA-21 in Stable and Unstable Angina Patients and Association with Aging

Table 1

Clinical information of the participants.

Characteristics	Control subjects (n = 50)	Stable angina (n = 82)	Unstable angina (n = 50)
Gender, male/female (n/n)	30/20	58/24	32/18	0.408	0.671	0.439
Age (yrs)	59.9 ± 7.2	63.7 ± 11.4	65.08 ± 9.1	0.270	0.536	0.331
HR(bpm)	71.02 ± 6.4	74 ± 5.3	75 ± 9.2	0.825	0.798	0.811
SBP (mmHg)	124.9 ± 5.41	135.6 ± 9.25	139.±13.14	0.190	0.476	0.607
DBP (mmHg)	74.8 ± 8.13	77.48 ± 10.25	80.71 ± 9.21	0.731	0.332	0.395
EF (%)	63.4 ± 8.7	59.4 ± 6.05	56 ± 7.21	0.075	0.064	0.332
Risk factors, n (%)
Current smoking	31 (62)	52 (64)	34 (67)	0.362	0.135	0.544
Hypertension	30 (59)	56 (68)	36 (72)	0.459	0.217	0.709
Hyperlipidemia	17 (33)	39 (48)	27 (54)	0.135	0.082	0.268
Type-2 DM	11 (22)	24 (29)	17 (33)	0.784	0.355	0.759
Family history of CHD	6 (11)	34 (41)	22 (43)	<0.001	<0.001	0.812
Laboratory information
Fasting glucose (mmol/L)	4.5 ± 0.9	5.34 ± 1.1	5.54 ± 1.1	0.267	0.218	0.530
C-reactive protein (mg/L)	1.2 ± .0.5	8.4 ± 1.5	11.5 ± 7.8	<0.001	<0.001	0.085
Total cholesterol (mmol/L)	4.21 ± 1.1	5.1 ± 1.6	5.48 ± 1.1	0.580	0.466	0.749
Total glyceride (mmol/L)	1.5 ± 0.9	1.63 ± 0.8	1.77 ± 1.6	0.372	0.075	0.214
High-density lipoprotein (mmol/L)	1.41 ± 0.2	1.12 ± 0.2	1.04 ± 0.6	0.628	0.431	0.429
Low-density lipoprotein (mmol/L)	2.9 ± 1.04	3.41 ± 1.8	3.62 ± 1.5	0.221	0.138	0.632
Creatinine (umol/L)	81.7 ± 16.1	84.4 ± 31.1	88.3 ± 42.2	0.536	0.459	0.846
Creatine kinase MB	0	9.08 ± 3.5	11.2 ± 1.7
Troponin I	0	0.02 ± 0.01	0.04 ± 0.06

Data are presented as mean ± SD. Abbreviations: HR, heart rate; bpm, beats/minute; SBP, systolic blood pressure; DBP, diastolic blood pressure; EF, ejection fraction; type-2 DM, diabetes mellitus; CHD, coronary heart disease; (controls and stable angina), (controls and unstable angina), and (stable angina and unstable angina).