Research Article
The Impact of Statins before High-Risk CABG on Postoperative Multiple Organ Function
Table 4
Independent risk factors for in-hospital MACCE.
| | | In-hospital MACCE | X2/t | value | Multivariate analysis OR (95% CI) | value | | YES (n = 271) | NO (n = 609) |
| | PST | 139 (51.3) | 364 (59.8) | 5.5 | 0.022 | 0.60 (0.44–0.81) | 0.001 | | ACE inhibitor or ARB | 48 (17.7) | 117 (19.2) | 0.3 | 0.641 | | | | Female gender | 117 (43.2) | 238 (39.1) | 1.3 | 0.265 | | | | Euroscore II | 9.2 ± 5.0 | 8.6 ± 3.2 | 26.7 | <0.0001 | 1.04 (1.01–1.08) | 0.018 | | BMI | 25.5 ± 3.8 | 24.7 ± 3.7 | 1.7 | 0.193 | | | | Hypertension | 178 (65.7) | 285 (46.8) | 26.8 | <0.0001 | 2.41 (1.78–3.28) | <0.0001 | | DM | 111 (41.0) | 260 (42.7) | 0.2 | 0.658 | | | | Current smoker | 96 (34.7) | 144 (23.6) | 13.1 | <0.0001 | 1.60 (1.16–2.21) | 0.004 | | Previous MI | 45 (16.6) | 66 (10.8) | 5.7 | 0.021 | 1.57 (1.03–2.40) | 0.035 | | Previous TIA or CVA | 29 (10.7) | 25 (4.1) | 14.2 | <0.0001 | 2.81 (1.60–4.93) | <0.0001 | | Previous PVD | 67 (24.7) | 124 (20.4) | 2.1 | 0.157 | | | | Hypercholesterolaemia | 110 (40.1) | 252 (41.2) | 0.05 | 0.882 | | | | Previous AF | 55 (20.3) | 75 (12.3) | 9.5 | 0.003 | 1.67 (1.12–2.45) | 0.011 | | Previous COPD | 38 (14.0) | 48 (7.9) | 8.0 | 0.001 | 2.28 (1.42–3.66) | 0.001 | | Ventricular aneurysm | 19 (7.0) | 59 (9.7) | 1.7 | 0.247 | | | | Moderate and poor LVEF (<50%) | 146 (53.9) | 250 (41.1) | 12.4 | 0.001 | 1.79 (1.33–2.42) | <0.0001 | | NYHA III and IV | 115 (42.4) | 200 (32.8) | 7.5 | 0.008 | 1.57 (1.17–2.11) | 0.003 | | Emergency CABG | 18 (6.6) | 29 (4.8) | 1.3 | 0.258 | | | | Off pump | 137 (56.5) | 331 (49.8) | 1.1 | 0.306 | | | | Duration of operation (hours) | 4.5 ± 1.3 | 4.3 ± 1.0 | 1.1 | 0.003 | 1.16 (1.02–1.32) | 0.022 |
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PST: preoperative statin therapy; CABG: coronary artery bypass grafting; MACCE: major adverse cardiovascular and cerebral events; LVEF: left ventricular ejection fraction; BMI: body mass index; MI: myocardial infarction; TIA: prior transient ischemic attacks; CVA: cerebral vascular accident; PVD: previous peripheral vascular diseases; DM: diabetes mellitus; NYHA : New York Heart Association, ACEI: angiotensin-converting enzyme inhibitors; ARB: angiotensin receptor blockers.
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