Research Article
The Impact of Statins before High-Risk CABG on Postoperative Multiple Organ Function
Table 5
Independent risk factors for AKI.
| | | AKI | X2/t | value | Multivariate analysis OR (95% CI) | value | | YES (n = 37) | NO (n = 843) |
| | PST | 10 (27.0) | 493 (58.5) | 14.3 | <0.0001 | 0.25 (0.12–0.54) | <0.0001 | | ACE inhibitor or ARB | 1 (2.7) | 164 (19.5) | 6.5 | 0.008 | 0.14 (0.02–1.01) | 0.052 | | Female gender | 17 (45.9) | 338 (40.1) | 0.5 | 0.497 | | | | Euroscore II | 7.8 ± 1.2 | 8.8 ± 3.9 | 17.7 | 0.112 | | | | BMI | 25.5 ± 3.3 | 24.9 ± 3.1 | 0.05 | 0.247 | | | | Hypertension | 24 (64.9) | 439 (52.1) | 2.3 | 0.134 | | | | Current smoker | 25 (67.6) | 215 (25.5) | 31.6 | <0.0001 | 6.98 (3.40–14.34) | <0.0001 | | Previous MI | 5 (13.5) | 106 (12.6) | 0.03 | 0.801 | | | | Previous TIA or CVA | 0 (0.0) | 54 (6.4) | 2.5 | 0.161 | | | | Previous PVD | 8 (21.6) | 183 (21.7) | 0.01 | 1.000 | | | | Previous AF | 7 (20.3) | 123 (12.3) | 0.5 | 0.476 | | | | Previous COPD | 5 (13.5) | 81 (9.6) | 0.6 | 0.397 | | | | Ventricular aneurysm | 19 (7.0) | 59 (9.7) | 1.7 | 0.247 | | | | Moderate and poor LVEF (<50%) | 15 (53.9) | 381 (41.1) | 0.3 | 0.615 | | | | Emergency CABG | 6 (16.2) | 41 (4.9) | 9.0 | 0.011 | 3.79 (1.50–9.58) | 0.005 | | Off pump | 24 (64.9) | 444 (52.7) | 2.1 | 0.178 | | | | Duration of operation (hours) | 6.9 ± 1.7 | 4.2 ± 0.9 | 44.5 | <0.0001 | 4.47 (3.27–6.12) | <0.0001 |
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PST: preoperative statin therapy; CABG: coronary artery bypass grafting; LVEF: left ventricular ejection fraction; BMI: body mass index; MI: myocardial infarction; TIA: prior transient ischemic attacks; CVA: cerebral vascular accident; PVD: previous peripheral vascular diseases; DM: diabetes mellitus; NYHA : New York Heart Association; ACEI: angiotensin-converting enzyme inhibitors; ARB: angiotensin receptor blockers.
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