| | Study | PICCOLETO [10] | BELLO [11, 12] | BASKET-SMALL2 [13] | RESTORE SVD China [14, 15] |
| | Year | 2010 | 2012 | 2018 | 2020 | | DCB/DES patients (n/n) | 28/29 | 90/92 | 382/376 | 116/114 | | Clinical follow-up time (months) | 9 | 24 | 12 | 24 | | Definition of SVD, in diameter (mm) | ≤2.75 mm | <2.8 mm | <3 mm in diameter | ≥2.25 and ≤2.75 mm | | Outcomes | MACE, death, MI, TLR | MACE, death, MI, TVR | MACE, cardiac death, MI, TVR | TLF, cardiac death, MI, TVR | | Type of DCB | Paclitaxel-coated balloon (Dior, Eurocor GmBH, Germany) | Paclitaxel-coated balloon (IN.PACT Falcon, Medtronic, USA) | Paclitaxel-coated balloon (SeQuent Please, B Braun Melsungen AG, Germany) | Paclitaxel-coated balloon (RESTORE, Cardionovum, Germany) | | Type of DES | First-generation paclitaxel-eluting stent (Taxus Liberté, Boston Scientific, USA) | First-generation paclitaxel-eluting stent (Taxus Liberté, Boston Scientific, USA) | everolimus-eluting stent (Xience, Abbott vascular, USA) or the second-generation paclitaxel-eluting stent (Taxus element, Boston Scientific, USA) | zotarolimus-eluting stent (RESOLUTE Integrity, Medtronic, USA) | | Balloon predilation in the DCB group (%) | 25 | 96.8 | 73 | 100 |
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DCB, drug-coated balloon; DES, drug-eluting stent; MACE, major adverse cardiac events; MI, myocardial infarction; TLF, target lesion failure; TLR, target lesion revascularization; TVR, target vessel revascularization; SVD, small vessel disease. MACE definition: PICCOLETO: death, new ST-elevation MI, and TLR; BELLO: death, Q- or non-Q-wave MI, or TVR; BASKET-SMALL2: cardiac death, non-fatal MI, and TVR.
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