Genotype Variations and Association between PAI-1 Promoter Region (4G/5G and -844G/A) and Susceptibility to Acute Myocardial Infarction and Chronic Stable Angina
Table 3
Distribution of genotype and allelic frequency and association analysis of 4G/5G polymorphism with AMI cases under different genetic models.
Genotype/allele
Group I (AMI) (n = 100)
Group III (control) (n = 100)
Odds ratio (95% CI)
value
4G/4G
31 (31%)
20 (20%)
6.51 (2.67–15.8)
<0.0001
4G/5G
59 (59%)
38 (38%)
6.52 (2.92–14.5)
<0.0001
5G/5G
10 (10%)
42 (42%)
Ref
Ref
value < 0.0001
Recessive model
4G/4G
31
20
1.79 (0.94–3.43)
0.076
4G/5G + 5G/5G
69
80
Dominant model
4G/5G + 4G/4G
90
58
6.51 (3.03–13.9)
<0.0001
5G/5G
10
42
Codominant model
4G/5G
59
38
2.34 (1.33–4.14)
0.003
5G/5G + 4G/4G
41
62
Allele
4G
120 (60%)
78 (39%)
2.34 (1.57–3.50)
<0.0001
5G
80 (40%)
122 (61%)
OR: odds ratio, CI: confidence interval, and n: number in sample. Significant at .
