Genotype Variations and Association between PAI-1 Promoter Region (4G/5G and -844G/A) and Susceptibility to Acute Myocardial Infarction and Chronic Stable Angina
Table 4
Distribution of genotype and allelic frequency and association analysis of 4G/5G polymorphism with CSA under different genetic models.
Genotype/allele
Group II (CSA) (n = 100)
Group III (control) (n = 100)
Odds ratio (95% CI)
value
4G/4G
32 (32%)
20 (20%)
2.10 (1.01–4.33)
0.044
4G/5G
36 (36%)
38 (38%)
1.24 (0.65–2.37)
0.509
5G/5G
32 (32%)
42 (42%)
Ref
Ref
P value—0.1240
Recessive model
4G/4G
32
20
1.88 (0.98–3.58)
0.054
4G/5G + 5G/5G
68
80
Dominant model
4G/5G + 4G/4G
68
58
1.53 (0.86–2.74)
0.144
5G/5G
32
42
Codominant model
4G/5G
36
38
0.91 (0.51–1.62)
0.769
5G/5G + 4G/4G
64
62
Allele
4G
100 (50%)
78 (39%)
1.56 (1.05–2.32)
0.027
5G
100 (50%)
122 (61%)
OR: odds ratio, CI: confidence interval, and n: number in sample. Significant at .
