Platelet Reactivity and Response to Aspirin and Clopidogrel in Patients with Platelet Count Disorders

Table 2

Platelet reactivity presented as a median and 25%–75% interquartile range, IQR.

Aggregation agonist	Aggregation in patients with thrombocytopenia	Aggregation in patients with thrombocythemia	Aggregation in controls	Statistical significance
	(1)	(2)	(3)
AA whole group (n = 174)	19 (7–28)	80 (79–118)	23 (15–38)	(2) vs. (1); (2) vs. (3)
AA on ASA only (n = 119)	14 (5–29)	80 (79–118)	23 (17–38)	(2) vs. (1); (2) vs. (3)
AA on DAPT only (n = 55)	19 (7–26)	80 (70–110)	20 (15–31)	(2) vs. (1); (2) vs. (3)
ADP whole group (n = 174)	32 (16–44)	124 (89–139)	50 (32–71)	(2) vs. (1); (2) vs. (3)
ADP on ASA only (n = 119)	36 (10–65)	136 (89–139)	52 (41–73)	(2) vs. (1); (2) vs. (3)
ADP on DAPT only (n = 55)	30 (18–41)	119 (114–124)	36 (21–67)	(2) vs. (1); (2) vs. (3)
TRAP whole group (n = 174)	41 (34–60)	137 (120–180)	90 (70–104)	(1) vs. (2); (2) vs. (3); (1) vs. (3)
TRAP on ASA only (n = 119)	36 (15–72)	137 (125–180)	86 (71–105)	(1) vs. (2); (2) vs. (3); (1) vs. (3)
TRAP on DAPT only (n = 55)	42 (39–53)	129 (104–139)	93 (65–103)	(1) vs. (2); (2) vs. (3); (1) vs. (3)

AU: arbitrary units, AA: arachidonic acid, ADP: adenosine diphosphate, TRAP: thrombin receptor-activating peptide, ASA–acetylsalicylic acid, DAPT: dual antiplatelet therapy, and IQR: 25%–75% interquartile range.