Review Article

Atrial Cardiomyopathy and Atrial Fibrillation in Cancer

Table 2

Atrial cardiomyopathy associated markers in patients with cancer

MarkerCancerAnticancer therapyCorrelationReference

Left atrial enlargementHER2-positive breast cancerTrastuzumab (TZ) therapyLA dilatation associated with the development of cardiotoxicityCorinna Bergamini
Breast cancerAnthracycline therapyMaximum LA volume significantly increased in the patientsYalin Tolga Yaylal
Solid cancer (gynecological, breast, gastrointestinal, sarcoma, lungs)Therapy-naiveLA reservoir and conduit functions were deteriorated in the cancer groupMarijana Tadic
Breast cancerChemotherapy and trastuzumab therapyLeft atrial longitudinal strain as a predictor of cancer therapeutics-related cardiac dysfunctionHyukjin Park

ECG abnormalitiesBreast cancerAnthracycline therapyLeft intraatrial and interatrial electromechanical intervals were prolongedYalin Tolga Yaylal
Chronic lymphocytic leukemia (CLL)IbrutinibLeft atrial abnormality identified by EKG can identify patients at increased risk for this toxicity.
Multiple cancerCardiac-directed radiation; anthracycline and/or alkylating chemotherapiesECG abnormalities are common among childhood cancer survivors and predictive of both cardiac and all-cause mortalityDaniel A. Mulrooney
Left atrial myxomaTumor excisionIncreased PTFV1 correlates with the tumor sizeNorihiro Komiya

NT-proBNPCoronary artery disease free of cancerNT-proBNP is an independent predictor of malignancies in patients with CADJosé Tuñón
Neuroendocrine tumor (NET)NT-proBNP are important markers in the diagnosis and survivalCatharina M. Korse
Multiple myeloma (MM)ChemotherapyElevated levels of NT-proBNP are associated with disease severityNoemi Pavo
Differentiated thyroid carcinomaTotal thyroidectomy and radioiodine ablationNT-proBNP associated with an increased risk for cardiovascular events and all-cause mortalityEsther N. Klein Hesselink
CancerBNP levels are elevated and an indicator of heart failureSachiko Bando
Breast cancerNot-high-dose chemotherapyNT-proBNP detects high risk of developing cardiotoxicityS. Romano
Non-Hodgkin lymphomaChemotherapyNT-proBNP is a marker for risk assessment for NHL patientsEva Gimeno
Metastatic renal cell carcinomaSunitinibNT-proBNP predicts for clinical benefit to sunitinib treatmentKonstantinos T. Papazisis