Incremental Value of Genotype Bins over the HAS-BLED Score for the Prediction of Bleeding Risk in Warfarin-Treated Patients with Atrial Fibrillation

Figure 2

Receiver operating characteristic curves of the HAS-BLED score with genotype bins defining highly sensitive responders for the prediction of bleeding events. HAS-BLED score plus genotype bins indicates the addition of the genotype bins related to highly sensitive responders (CYP2C9 13 + VKORC1-1639A/A, CYP2C933 + VKORC1-1639 A/A, CYP2C933 + VKORC1-1639G/A, or CYP2C933 + VKORC1-1639G/G) to HAS-BLED score ≥3. (a) Any clinically relevant bleeding. (b) Major bleeding.

(a)

(b)