Incremental Value of Genotype Bins over the HAS-BLED Score for the Prediction of Bleeding Risk in Warfarin-Treated Patients with Atrial Fibrillation

Table 3

Independent contribution of the HAS-BLED score and genotype bins defining warfarin response to bleeding events.

Variable	Any clinically relevant bleeding		Major bleeding
	Hazard ratio (95% CI)	^aAdjusted	Hazard ratio (95% CI)	^aAdjusted
HAS-BLED score ≥3	2.75 (1.60–4.74)	0.001	3.93 (1.52–10.16)	0.005
Highly sensitive responder	3.85 (1.88–7.91)	0.001	3.75 (1.17–11.97)	0.03
HAS-BLED score ≥3 plus highly sensitive responder	3.39 (2.01–5.73)	0.001	5.53 (2.03–15.01)	0.001

Highly sensitive responders were defined as carriers of the genotype bins CYP2C9 13 + VKORC1-1639A/A, CYP2C933 + VKORC1-1639 A/A, CYP2C933 + VKORC1-1639G/A, or CYP2C9 33 + VKORC1-1639G/G. ^aAdjusted for age, sex, alcohol intake, aimed INRs, concomitant medications, and comorbidity conditions.