Incremental Value of Genotype Bins over the HAS-BLED Score for the Prediction of Bleeding Risk in Warfarin-Treated Patients with Atrial Fibrillation

Table 4

C-indices of the ROC curves, ROC curve comparison, IDI and NRI of the HAS-BLED score plus genotype bins defining warfarin response compared to the HAS-BLED score.

	C-index	95% CI			IDI (%)		NRI (%)
Any clinically relevant bleeding
HAS-BLED score plus genotype bins	0.64	0.60–0.69	<0.001	0.03	3.35	0.001	55.68	<0.001
HAS-BLED score	0.60	0.56–0.64	0.001
Major bleeding
HAS-BLED score plus genotype bins	0.70	0.66–0.74	<0.001	0.21	1.43	0.210	30.30	0.130
HAS-BLED score	0.64	0.61–0.69	0.020

HAS-BLED score plus genotype bins indicate the addition of the genotype bins related to highly sensitive responder (CYP2C913 + VKORC1-1639A/A, CYP2C933 + VKORC1-1639A/A, CYP2C933 + VKORC1-1639G/A, or CYP2C933 + VKORC1-1639G/G) to HAS-BLED score ≥3. CI, confidence interval; IDI, integrated discriminatory improvement; NRI, net reclassification improvement. For c-index comparison.