Correlation between Serum Platelet Count and Cognitive Function in Patients with Atrial Fibrillation: A Cross-Sectional Study

Table 1

Baseline characteristics of participants.

Platelets (10^9/L)	T1 ＜172	T2 172–225	T3 ＞225	value
N	83	85	86
Age (year)	68.46 ± 11.32	67.56 ± 10.08	66.10 ± 9.92	0.165
Sex, n (%)				0.006
Female	56 (67.47)	48 (56.47)	37 (43.02)
Male	27 (32.53)	37 (43.53)	49 (56.98)
Degree of education, n (%)				0.240
Illiterate	24 (28.92)	30 (35.29)	30 (34.88)
Primary and junior high school	43 (51.81)	36 (42.35)	40 (46.51)
High school	10 (12.05)	9 (10.59)	14 (16.28)
Undergraduate and above	6 (7.23)	10 (11.76)	2 (2.33)
Smoking or not, n (%)				0.185
Nonsmoker	42 (50.60)	48 (56.47)	57 (66.28)
Current smoker	19 (22.89)	22 (25.88)	17 (19.77)
Quit	22 (26.51)	15 (17.65)	12 (13.95)
Alcohol consumption, n (%)				0.137
Nondrinker	51 (61.45)	61 (71.76)	67 (77.91)
Current drinker	20 (24.10)	16 (18.82)	15 (17.44)
Quit	12 (14.46)	8 (9.41)	4 (4.65)
BMI (kg/m^2)	24.64 ± 4.32	26.06 ± 4.47	25.23 ± 3.98	0.132
Hb (g/L)	131.89 ± 21.09	138.41 ± 17.84	134.20 ± 19.38	0.176
RBC (10^12/L)	4.20 ± 0.67	4.51 ± 0.63	4.52 ± 0.66	0.003
PT (s)	15.70 ± 8.52	14.98 ± 10.01	13.53 ± 6.75	0.008
INR	1.42 ± 0.80	1.33 ± 0.88	1.20 ± 0.60	0.007
APTT (s)	33.02 ± 8.04	32.95 ± 8.18	31.34 ± 4.45	0.209
D-dimer (mg/L)	1.21 ± 2.24	0.87 ± 1.53	0.81 ± 0.91	0.068
FT3 (pmol/L)	4.66 ± 3.82	5.00 ± 2.69	4.76 ± 3.42	0.025
FT4 (pmol/L)	19.38 ± 10.61	18.12 ± 6.34	19.87 ± 13.79	0.554
TSH (mIU/L)	3.59 ± 4.48	3.00 ± 3.16	2.79 ± 2.14	0.597
Creatinine (umol/L)	81.31 ± 28.80	71.88 ± 24.03	71.99 ± 37.10	0.007
Urea (mmol/L)	8.42 ± 4.07	6.75 ± 3.37	6.87 ± 3.64	<0.001
UA (umol/L)	371.50 (30.00–745.00)	344.00 (192.00–1096.00)	345.00 (163.00–778.00)	0.044
AST (U/L)	22.00 (6.60–618.00)	19.00 (6.30–3319.00)	20.00 (5.20–1847.00)	0.248
ALT (U/L)	16.90 (5.50–258.70)	21.00 (7.20–1373.30)	19.30 (3.70–1095.90)	0.502
Lipoprotein (mg/L)	172.50 (3.00–1015.00)	164.50 (3.00–804.00)	214.00 (3.00–1091.00)	0.347
TC (mmol/L)	3.46 ± 0.91	3.87 ± 0.90	3.95 ± 1.01	0.002
TG (mmol/L)	0.99 ± 0.59	1.33 ± 0.68	1.27 ± 0.60	<0.001
HDL (mmol/L)	1.03 ± 0.26	1.08 ± 0.26	1.08 ± 0.30	0.609
LDL (mmol/L)	2.02 ± 0.70	2.28 ± 0.75	2.37 ± 0.74	0.012
LVEF (%)	46.96 ± 13.86	50.27 ± 11.29	52.65 ± 10.45	0.015
MoCA score	18.87 ± 6.58	19.58 ± 6.43	19.14 ± 7.42	0.800
Hypertension, n (%)				0.224
No	45 (54.22)	36 (42.35)	37 (43.02)
Yes	38 (45.78)	49 (57.65)	49 (56.98)
Diabetes mellitus, n (%)				0.479
No	66 (79.52)	62 (72.94)	62 (72.09)
Yes	17 (20.48)	23 (27.06)	24 (27.91)
Heart failure, n (%)				0.009
No	25 (30.12)	44 (51.76)	42 (48.84)
Yes	58 (69.88)	41 (48.24)	44 (51.16)
Coronary artery disease, n (%)				0.003
No	26 (31.33)	13 (15.29)	10 (11.63)
Yes	57 (68.67)	72 (84.71)	76 (88.37)
Myocardial infarction, n (%)				0.338
No	77 (92.77)	75 (88.24)	81 (94.19)
Yes	6 (7.23)	10 (11.76)	5 (5.81)
Hyperlipidemia, n (%)				0.375
No	81 (97.59)	83 (97.65)	81 (94.19)
Yes	2 (2.41%)	2 (2.35)	5 (5.81)
Valvular disease, n (%)				0.050
No	47 (56.63)	62 (72.94)	61 (70.93)
Yes	36 (43.37)	23 (27.06)	25 (29.07)
Cerebral infarction history, n (%)				0.304
No	68 (81.93)	68 (80.00)	76 (88.37)
Yes	15 (18.07)	17 (20.00)	10 (11.63)
Aspirin, n (%)				0.746
No	56 (67.47)	53 (62.35)	54 (62.79)
Yes	27 (32.53)	32 (37.65)	32 (37.21)
Warfarin, n (%)				0.295
No	70 (84.34)	73 (85.88)	79 (91.86)
Yes	13 (15.66)	12 (14.12)	7 (8.14)
Clopidogrel, n (%)				0.573
No	79 (95.18)	78 (91.76)	78 (90.70)
Yes	4 (4.82)	7 (8.24)	8 (9.30)
Rivashaban, n (%)				0.293
No	77 (92.77)	79 (92.94)	84 (97.67)
Yes	6 (7.23)	6 (7.06)	2 (2.33)
Type of AF, n (%)				0.269
Paroxysmal AF	21 (25.30)	32 (37.65)	23 (26.74)
Persistent AF	45 (54.22)	32 (37.65)	47 (54.65)
Long-term persistent AF	7 (8.43)	11 (12.94)	6 (6.98)
Permanent	10 (12.05)	10 (11.76)	10 (11.63)
Duration of AF, n (%)				0.323
≤1 year	28 (33.73)	31 (36.47)	43 (50.00)
1–5 years	29 (34.94)	24 (28.24)	23 (26.74)
6–10 years	10 (12.05)	13 (15.29)	9 (10.47)
＞10 years	16 (19.28)	17 (20.00)	11(12.79)

Hb, hemoglobin; RBC, red blood cell; PT, prothrombin time; INR, International Normalized Ratio; APTT, activated partial thromboplastin time; FT3, free triiodothyronine; FT4, free thyroxine; TSH, thyroid-stimulating hormone; UA, uric acid; AST, aspartate transaminase; ALT, alanine aminotransferase; TC, total cholesterol; TG, triacylglycerol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.  < 0.05 is considered to be statistically significant.