Research Article

Correlation between Serum Platelet Count and Cognitive Function in Patients with Atrial Fibrillation: A Cross-Sectional Study

Table 2

Univariate analysis for cognitive function of atrial fibrillation patients.

CovariateStatisticsβ (95%CI) value

Age (year)59.71 ± 11.141.03 (1.02–1.04)<0.001
Sex, n (%)
 Male141 (55.51%)Reference<0.001
 Female113 (44.49%)−4.91 (−6.46, −3.36)
Degree of education, n (%)
 Illiterate84 (33.07%)Reference
 Primary and junior high school119 (46.85%)6.82 (5.32, 8.31)<0.001
 High school33 (12.99%)10.79 (8.62, 12.96)<0.001
 Undergraduate and above18 (7.09%)11.81 (9.19, 14.44)<0.001
Smoking or not, n (%)
 Nonsmoker147 (57.87%)Reference
 Current smoker58 (22.83%)3.89 (1.91, 5.87)<0.001
 Quit49 (19.29%)3.67 (1.57, 5.77)<0.001
Alcohol consumption, n (%)
 Nondrinker179 (70.47%)Reference
 Current drinker51 (20.08%)4.96 (2.98, 6.95)<0.001
 Quit24 (9.45%)2.82 (0.06, 5.58)0.047
 PLT208.1 ± 68.20.00 (−0.01, 0.01)0.575
 BMI25.33 ± 4.270.35 (0.16, 0.54)<0.001
 Hb (g/L)134.85 ± 19.580.08 (0.03, 0.12)<0.001
 RBC (10^12/L)4.41 ± 0.671.44 (0.19, 2.69)0.024
 PT (s)12.15 (10.00–66.00)−0.07 (−0.17, 0.03)0.154
 INR1.32 ± 0.77−0.87 (−1.94, 0.21)0.115
 APTT (s)32.53 ± 7.260.10 (−0.01, 0.21)0.084
 D-dimer (10^12/L)0.55 (0.04–15.37)−1.00 (−1.51, −0.50)<0.001
 FT3 (pmol/L)4.31 (0.94–31.80)0.08 (−0.18, 0.35)0.546
 FT4 (pmol/L)17.60 (3.72–100.00)−0.05 (−0.14, 0.03)0.196
 TSH (mIU/L)2.40 (0.01–33.30)0.01 (−0.25, 0.27)0.945
 Creatinine (umol/L)74.92 ± 30.66−0.00 (−0.03, 0.02)0.778
 Urea (mmol/L)7.31 ± 3.74−0.24 (−0.47, −0.02)0.034
 UA (umol/L)376.68 ± 129.030.00 (−0.01, 0.01)0.854
 AST (U/L)20.00 (5.20–3319.00)−0.00 (−0.00, 0.00)0.397
 ALT (U/L)19.90 (3.70–1373.30)−0.00 (−0.01, 0.01)0.660
 Lipoprotein (mg/L)188.00 (3.00–1091.00)0.00 (−0.00, 0.00)0.617
 TC (mmol/L)3.77 ± 0.96−0.49 (−1.38, 0.40)0.280
 TG (mmol/L)1.20 ± 0.640.74 (−0.59, 2.08)0.275
 HDL (mmol/L)1.07 ± 0.28−0.66 (−3.74, 2.43)0.678
 LDL (mmol/L)2.23 ± 0.74−0.59 (−1.74, 0.56)0.312
 LVEF (%)50.09 ± 12.050.03 (−0.04, 0.10)0.354
Hypertension, n (%)
 No118 (46.46%)Reference
 Yes136 (53.54%)−0.51 (−2.16, 1.14)0.545
Diabetes mellitus, n (%)
 No190 (74.80%)Reference
 Yes64 (25.20%)0.54 (−1.37, 2.44)0.580
Heart failure, n (%)
 No111 (43.70%)Reference
 Yes143 (56.30%)−3.45 (−5.05, −1.84)<0.001
Coronary artery disease, n (%)
 No49 (19.29%)Reference
 Yes205 (80.71%)−0.46 (−2.52, 1.61)0.665
Myocardial infarction, n (%)
 No233 (91.73%)Reference0.253
 Yes21 (8.27%)−1.76 (−4.78, 1.26)
Hyperlipidemia, n (%)
 No245 (96.46%)Reference0.026
 Yes9 (3.54%)5.11 (0.64, 9.58)
Valvular disease, n (%)
 No170 (66.93%)Reference
 Yes84 (33.07%)−2.32 (−4.04, −0.59)0.009
Cerebral infarction history, n (%)
 No212 (83.46%)Reference0.600
 Yes42 (16.54%)−0.60 (−2.84, 1.64)
Aspirin, n (%)
 No163 (64.17%)Reference0.082
 Yes91 (35.83%)1.53 (−0.18, 3.24)
Warfarin, n (%)
 No222 (87.40%)Reference0.712
 Yes32 (12.60%)0.47 (−2.01, 2.95)
Clopidogrel, n (%)
 No235 (92.52%)Reference0.765
 Yes19 (7.48%)0.48 (−2.69, 3.65)
Rivashaban, n (%)
 No240 (94.49%)Reference0.676
 Yes14 (5.51%)0.76 (−2.78, 4.29)
Type of AF, n (%)
 Paroxysmal AF76 (29.92%)Reference
 Persistent AF124 (48.82%)−1.61 (−3.51, 0.30)0.099
 Long-term persistent AF24 (9.45%)−0.01 (−3.11, 3.08)0.993
 Permanent30 (11.81%)−0.59 (−3.40, 2.22)0.680
Duration of AF, n (%)
 ≤1 year102 (40.16%)Reference
 1–5 years76 (29.92%)0.20 (−1.79, 2.20)0.842
 6–10 years32 (12.60%)0.67 (−2.04, 3.37)0.629
 >10 years44 (17.32%)−0.51 (−2.92, 1.89)0.676

Hb, hemoglobin; RBC, red blood cell; PT, prothrombin time; INR, International Normalized Ratio; APTT, activated partial thromboplastin time; FT3, free triiodothyronine; FT4, free thyroxine; TSH, thyroid-stimulating hormone; UA, uric acid; AST, aspartate transaminase; ALT, alanine aminotransferase; TC, total cholesterol; TG, triacylglycerol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; CI, confidence interval.  < 0.05 is considered to be statistically significant.