Circulating miRNA-29b and Sclerostin Levels Correlate with Coronary Artery Calcification and Cardiovascular Events in Maintenance Hemodialysis Patients

<div>Serum levels of sclerostin and miRNA-29b were correlated with CAC in MHD patients. (a) The serum level of sclerostin among the CAC (&lt;100) (n = 44), CAC (100–400) (n = 27), and CAC (&gt;400) (n = 34) groups was determined by ELISA. (b) A miRNA-mRNA target prediction using the RNA22 database presented sclerostin as the target of miRNA-29b. (c) The serum expression level of miRNA-29b (Ct) among the CAC (&lt;100) (n = 44), CAC (100–400) (n = 27), and CAC (&gt;400) (n = 34) groups was determined by RT-qPCR. (d) A negative correlation between serum levels of sclerostin and miRNA-29b in MHD patients (n = 105).</div>

Cardiology Research and Practice

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Figure 1

Figure 1: Circulating miRNA-29b and Sclerostin Levels Correlate with Coronary Artery Calcification and Cardiovascular Events in Maintenance Hemodialysis Patients 

Figure 1 | Circulating miRNA-29b and Sclerostin Levels Correlate with Coronary Artery Calcification and Cardiovascular Events in Maintenance Hemodialysis Patients 