ANGPTL4 Attenuates Ang II-Induced Atrial Fibrillation and Fibrosis in Mice via PPAR Pathway

Figure 1

ANGPTL4 attenuates Ang II-induced AF. Mice were infused with Ang II and treated with ANGPTL4 (20 μg/kg, once a day) for 3 weeks. (a) ANGPTL4 mRNA levels are significantly elevated in atria of Ang-II-induced mice models. (b) Representative bands of the ANGPTL4 protein level in Ang-II-induced mice models. (c) Quantification of ANGPTL4 protein level in Ang-II-induced mice models. (d) Representative atrial electrogram recordings after burst pacing in mice. (e) RR interval, (f) QRS interval, and (g) QT interval after burst pacing in mice of three groups are shown (n = 6 mice per group).  < 0.001 vs. control group; ^## < 0.01, ^### < 0.001 vs. Ang II group.

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