Research Article
miR-149 Alleviates Ox-LDL-Induced Endothelial Cell Injury by Promoting Autophagy through Akt/mTOR Pathway
Figure 4
Enhanced autophagy and suppressed Akt/mTOR mediate the protective effects of miR-149 mimics. The inhibitor of autophagy (3-methyladenine, 3-MA, 100 μm) and activator of Akt/mTOR pathway (insulin, 200 nm) were used. (a) Cell viability of HUVECs. (b) Caspase-3 activity of HUVECs. vs. control group; and vs. ox-LDL group; and vs. miR-149 group.
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