Research Article

Effect of PCSK9 Inhibitor on Contrast-Induced Acute Kidney Injury in Patients with Acute Myocardial Infarction Undergoing Intervention Therapy

Table 3

Comparison of baseline data between the CI-AKI and non-CI-AKI groups.

Non-CI-AKI group (n = 267)CI-AKI group (n = 42)χ2/t/Z value

Male sex, n (%)194 (72.66)28 (66.67)0.640.42
Age (years), mean, SD63.07, 10.7865.14, 9.45−1.180.24
STEMI, n (%)173 (64.79)29 (69.05)0.290.59
Old MI, n (%)45 (16.85)9 (21.43)0.530.47
Diabetes mellitus, n (%)90 (50.85)25 (59.52)10.35<0.01
Hypertension, n (%)154 (57.68)30 (71.43)2.850.09
SBP (mmHg), median (IQR)134.00 (123.00–145.00)135.00 (122.50–150.50)−1.000.32
DBP (mmHg), median (IQR)78.00 (70.00–86.00)80.00 (69.75–90.50)−0.730.47
Evolocumab, n (%)139 (52.06)10 (23.81)11.60<0.01
Atorvastatin, n (%)147 (55.06)24 (57.14)0.060.80
RAAS inhibitors, n (%)229 (85.77)40 (95.24)2.890.09
Killip class I, n (%)260 (97.38)38 (90.48)5.040.03
LVEF (%), median (IQR)51.00 (46.00–56.00)50.00 (42.00–56.25)−1.110.27
NT-pro-BNP (ng/L), median (IQR)679.00 (212.50–1475.00)852.50 (428.00–2489.00)−1.560.12
TNT (ng/mL), median (IQR)1.59 (0.54–3.19)1.50 (0.55–6.67)−0.870.39
Hb (g/L), median (IQR)133.00 (123.00–144.00)137.00 (126.00–148.00)−1.300.20
Hs-CRP (mg/L), median (IQR)5.19 (2.10–18.60)9.35 (2.64–15.63)−1.180.24
HDL-C (mmol/L), median (IQR)1.01 (0.86–1.23)1.05 (0.82–1.35)−0.560.58
LDL-C (mmol/L), median (IQR)3.17 (2.46–4.21)3.35 (2.57–3.75)−0.540.59
Contrast agent (mL), median (IQR)140.00 (130.00–150.00)140.00 (130.00–150.00)0.650.52
Emergency PCI, n (%)171 (64.04)31 (73.81)1.530.22
Preoperative hydration, n (%)60 (28.99)12 (28.57)0.760.39
Postoperative hydration, n (%)263 (98.50)41 (97.62)0.180.67
Iodixanol, n (%)233 (87.27)39 (92.86)1.080.30

χ2/t/Z, a test used to compare parameters. CI-AKI, contrast-induced acute renal injury; SD, standard deviation; STEMI, ST-segment elevation myocardial infarction; MI, myocardial infarction; SBP, systolic blood pressure; IQR, interquartile range; DBP, diastolic blood pressure; RAAS, renin-angiotensin-aldosterone system; LVEF, left ventricular ejection fraction; NT-pro-BNP, N-terminal pro-brain natriuretic peptide; TNT, troponin T; Hb, hemoglobin; hs-CRP, high-sensitivity C-reactive protein; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; PCI, percutaneous coronary intervention.