Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population

Table 1

Baseline characteristic of subjects.

Index	ACS, n = 40	CCS, n = 63	Intact, n = 25
Age, years^2	58.35 ± 9.17	60.35 ± 7.95	55.4 ± 9.03	0.209^b	0.013^b
Gender, men/women	35/5	55/8	20/5	0.415	0.384
BMI, kg/m2^2	28.69 ± 4.08	30.24 ± 4.97	31.18 ± 5.99	0.051^b	0.452^b
AH, n (%)	29 (72.5)	51 (81)	19 (76)	0.755	0.603
Smoker, n (%)	17 (42.5)	11 (17.5)	5 (20)	0.062	0.781
Cholesterol, mmol/L^2	4.43 ± 1.15	4.44 ± 1.18	4.76 ± 1.67	0.365^b	0.324^b
Triglyceride, mmol/L	1.44 ± 0.75^1	1 (0.84–1.29)^2	1.24 ± 0.58^1	0.295^b	0.369^а
HDL, mmol/L^2	1.02 (0.89–1.14)^2	1.09 ± 0.31^1	1.07 (0.91–1.44)^2	0.279^a	0.439^b
LDL, mmol/L	2.61 (2.2–3.38)	2.73 (2.07–3.44)	2.8 (1.99–3.36)	0.805^a	0.628^а
Glucose, mmol/L^1	5.35 (4.6–6.9)	4.7 (4.2–5.78)	3.89 (3.53–4.58)	0.001^a	0.01^а
Fibrinogen, g/L^1	2.2 (2–2.8)	3.7 (2.4–27.1)	3 (2.55–3.2)	0.003^a	0.038^а
GFR (ЕРІ), ml/min^2	70.89 ± 21.87	74.41 ± 18.83	79.91 ± 27.8	0.242^b	0.395^b
АLТ, U/L^1	99.05 (52.98–212.88)	26.35 (19.18–36.08)	25.35 (19.3–33.28)	<0.001^a	0.811^а
АSТ, U/L^1	45.2 (26.78–66.58)	28 (22.6–35.9)	22.25 (19.88–27.73)	0.003^a	0.168^а
ММР-9,^1	449.4 (151.15–624.5)	354.35 (149.98–575.58)	67.97 (34.88–303.6)	0.002^а	0.004^а
Erythrocytes, ×10^12/L,^2	4.52 ± 0.54	4.41 ± 0.51	4.46 ± 0.7	0.749^b	0.733^b
Hemoglobin, g/L^2	148.34 ± 16.79	145.4 ± 14.84	147.11 ± 16.85	0.799^b	0.679^b

ACS: acute coronary syndrome; CCS: chronic coronary syndrome; intact: patients with intact coronary arteries; n: number of cases; BMI: body mass index; AH: arterial hypertension; HDL: high-density lipoprotein; LDL: low-density lipoprotein; GFR (ЕРІ): glomerular filtration rate (according to the chronic kidney disease epidemiology collaboration); АLТ: alanine aminotransferase; АSТ: aspartate aminotransferase. ¹Data are given in the form of median and interquartile range. ²Data are given as mean and standard deviation. ^aComparison was performed using the Mann–Whitney criterion. ^bComparison was performed using Student’s t-criterion. : value for ACS and intact group comparison; : value for CCS and intact group comparison.