Sex Disparity in Characteristics, Management, and In-Hospital Outcomes of Patients with ST-Segment Elevated Myocardial Infarction: Insights from Henan STEMI Registry

Table 3

Odds ratio for in-hospital death, death or treatment withdrawal, and MACCE in women over men with adjustment for a different set of variables, and percent of the gender-associated hazard difference accounted by each set of explaining variables.

Variables adjusted for	In-hospital death			Death or treatment withdrawal			MACCE
	Adjust OR (95% CI) (women vs. men)	value	% of diff accounted	Adjust OR (95% CI) (women vs. men)	value	% of diff accounted	Adjust OR (95% CI) (women vs. men)	value	% of diff accounted
Base model	2.30 (1.71, 3.11)	<0.001	—	2.88 (2.32, 3.57)	<0.001	—	2.27 (1.88, 2.74)	<0.001	—
+Age	1.54 (1.13, 2.11)	0.007	−58.46	1.77 (1.41, 2.22)	<0.001	−59.04	1.48 (1.21, 1.81)	<0.001	−62.20
+Hospital grade	2.33 (1.73 3.13)	<0.001	2.31	2.86 (2.30, 3.56)	<0.001	−1.06	2.26 (1.87, 2.73)	<0.001	−0.79
+Socioeconomic status	2.41 (1.77, 3.28)	<0.001	8.46	2.71 (2.17, 3.39)	<0.001	−9.04	2.16 (1.78, 2.62)	<0.001	−8.66
+Cardiovascular risk factors	1.77 (1.27,2.46)	0.001	−40.77	2.14 (1.67, 2.73)	<0.001	−39.36	1.74 (1.40, 2.14)	<0.001	−41.73
+Medical history	2.26 (1.67, 3.05)	<0.001	−3.08	2.81 (2.26, 3.50)	<0.001	−3.72	2.25 (1.86, 2.72)	<0.001	−1.57
+ Clinical characteristics	2.19 (1.60, 2.99)	<0.001	−8.46	2.83 (2.24, 3.57)	<0.001	−2.66	2.19 (1.79, 2.68)	<0.001	−6.30
+Time to present	2.42 (1.80, 3.25)	<0.001	9.23	2.84 (2.28, 3.53)	<0.001	−2.13	2.25 (1.86, 2.72)	<0.001	−1.57
+Acute drugs	2.22 (1.65, 3.00)	<0.001	−6.15	2.74 (2.20, 3.41)	<0.001	−7.45	2.20 (1.82, 2.66)	<0.001	−5.51
+Reperfusion therapy	2.20 (1.62, 2.98)	<0.001	−7.69	2.70 (2.13, 3.35)	<0.001	−9.57	2.14 (1.76, 2.60)	<0.001	−10.24
All above	1.61 (1.12, 2.33)	0.012	−53.08	1.68 (1.26, 2.24)	<0.001	−63.83	1.37 (1.08, 1.74)	0.011	−70.87

Base model: adjusted for clustering of patients within hospitals. Age: continuous variables. Hospital grade: second hospital or tertiary hospital. Socioeconomic status: marriage status and occupation. Cardiovascular risk factors: hypertension, dyslipidemia, diabetes, and current smoker. Medical history: a medical history of coronary heart disease, heart failure, stroke, and chronic kidney diseases. Clinical characteristics: myocardial ischemia symptoms, heart rate, systolic blood pressure, Killip class, cardiac arrest, and anterior myocardial infarction at admission. Time to present: time from symptom onset to first medical contact at the hospital. Acute drugs: aspirin, P2Y12, and statin at emergency. Reperfusion therapy: successful reperfusion or not. Percent of sex difference account: (OR−unadjusted OR)/(unadjusted OR−1.0)100%.