Distinguishing Cardiac Amyloidosis and Hypertrophic Cardiomyopathy by Thickness and Myocardial Deformation of the Right Ventricle

Table 5

Receiver operating characteristic curves of different CMR indices for the distinction between CA and HCM.

Variables	AUC	95% CI	value	Cutoff	Sens, %	95% CI	Spec, %	95% CI	+LR	−LR	+PV	−PV
RVEF%	0.68	0.59–0.76	0.0003	≤39.86	52.54	39.1–65.7	79.66	67.2–89.0	2.58	0.6	72.10	62.70
RV-GRPS	0.79	0.70–0.86	0.0001	≤10.19	52.54	39.1–65.7	89.83	79.2–96.1	5.17	0.53	83.80	65.40
RV-GCPS	0.70	0.61–0.78	0.0001	≥−2.63	45.76	32.7–59.2	86.44	75.0–93.9	3.38	0.63	77.10	61.40
RV-GLPS	0.88	0.80–0.93	0.0001	≥−5.87	76.27	63.4–86.4	86.40	75.0–93.9	5.63	0.27	84.90	78.50
RVT	0.81	0.73–0.89	0.0001	≥6.70	73.33	60.3–83.9	83.33	71.5–91.7	4.4	0.32	81.50	75.80
RVT + RV-GRPS	0.86	0.78–0.91	0.0001	≤0.38	71.20	57.9–82.2	86.40	75.0–93.9	5.25	0.33	84.00	75.00
RVT + RV-GCPS	0.84	0.76–0.89	0.0001	≤0.47	79.70	67.2–89.0	81.40	69.1–90.3	4.27	0.25	81.00	80.00
RVT + RV-GLPS	0.92	0.85–0.96	0.0001	≤0.36	81.36	69.1–90.3	89.83	79.2–96.1	8.00	0.21	88.90	82.80

CA, cardiac amyloidosis; HCM, hypertrophic cardiomyopathy; CMR, cardiac magnetic resonance; RVEF, right ventricular ejection fraction; GCPS, global circumferential peak strain; GLPS, global longitudinal peak strain; GRPS, global radial peak strain; RVT, right ventricular thickness; AUC, area under the curve; Sens, sensibility; Spec, specificity; +LR, positive likelihood ratio; −LR, negative likelihood ratio; +PV, positive predictive value; −PV, negative predictive value.