The Effect of Antihypertensive Drugs on NADH in Newly Diagnosed Primary Hypertension

Table 5

Summary of continuous measures for hypertensive patients assigned to metoprolol at 50 mg BID. values of the paired analysis of continuous data with a nonparametric Wilcoxon test for comparison of results before and after the six-week treatment.

Parameter	Median v1 (Q1–Q3)	Median v2 (Q1–Q3)
DTHR (beats/min)	81.11 (77.02–89.21)	68.36 (65.93–73.73)	<0.0001
DTSBP (mmHg)	149.14 (143.49–156.49)	138.18 (128.65–144.28)	0.001
DTDBP (mmHg)	89.21 (84.26–92.83)	82.29 (74.88–84.93)	0.0017
NTHR (beats/min)	64.04 (60.76–67.59)	57.61 (53.02–63.46)	0.0003
NTSBP (mmHg)	130.76 (120.71–137.34)	114.65 (107.48–123.16)	0.0003
NTDBP (mmHg)	73.63 (68.52–81.62)	62.42 (58.17–69.15)	0.0013
24-hHR (beats/min)	77.74 (74.06–83.78)	67.13 (63.82–70.69)	<0.0001
24-hSBP (mmHg)	144.73 (141.09–150.52)	133.88 (125.23–138.88)	0.0004
24-hDBP (mmHg)	83.86 (81.57–90.38)	79.24 (71.47–81.98)	0.0008
Bmean (kFU)	698.78 (508.65–847.20)	841.20 (614.19–950.31)	0.0034
FImax (kFU)	762.31 (545.56–901.12)	900.81 (658.66–1046.42)	0.0034
FRmin (kFU)	578.17 (425.36–715.79)	674.15 (508.32–804.51)	0.0052
Imax (kFU)	43.59 (38.66–72.42)	53.08 (35.33–109.49)	0.9799
Rmin (kFU)	108.34 (70.17–143.78)	139.98 (103.53–168.55)	0.0214
IRampl (kFU)	149.88 (104.86–223.99)	188.66 (150.42–264.23)	0.0182
CImax	0.32 (0.29–0.38)	0.34 (0.23–0.41)	0.2312

Bmean, mean fluorescence recorded before ischemia as the baseline value; FImax, the maximal fluorescence above the baseline during ischemia; FRmin, the minimal fluorescence below the baseline during reperfusion; Imax, the difference between FImax and Bmean; IRampl, the difference between FImax and FRmin; Rmin, the difference between Bmean and FRmin; CImax, Imax/IRampl rate; 24-hSBP, 24-hour systolic blood pressure; 24-hDBP, 24-hour diastolic blood pressure; 24-hPR, 24-hour pulse rate; DTSBP, day time systolic blood pressure; DTDBP, day time diastolic blood pressure; DTPR, day time pulse rate; NTSBP, night time systolic blood pressure; NTDBP, night time diastolic blood pressure; and NTPR, night time pulse rate.