|
| Study | Sample size | Ages | Training protocols | Program duration |
| T/C (M/F) | T/C | HIIT | MICT |
|
| Cardozo et al., 2015 | 23 (14, 9)/48 (34, 14) | T: 56 ± 12 | 10 bouts ∗ 2 min (>90% HRpeak) | 30 min of continuous training (at 70 to 75% of HRpeak) | 16 weeks |
| C: 62 ± 12 | Each interval: 2 min (<60% HRpeak) |
|
| Choi et al., 2018 | 23 (21, 2)/21 (18,) | T: 60 ± 11 | 4 bouts ∗ 4 min (at 85–100% of the HRpeak) | 28 min of continuous training (at 60 to 70% of HRpeak) | 9-10 weeks |
| C: 62.8 ± 11.9 | Each interval: 3 min (at 50–60% of the HRpeak) |
|
| Conraads et al., 2015 | 85 (NA)/89 (NA) | NA | 4 bouts ∗ 4 min (at 85–90% of peak VO2 | 37 min of continuous training (at least 60–70% of peak VO2, at least 65–75% of HRpeak) | 12 weeks |
| 90–95% of HRpeak, 15–17 Borg scale, and shortness of breath) |
| Each interval: 3 min (at 50–70% of HRpeak) |
|
| Currie et al.,2013 | 11 (NA)/11 (NA) | T: 63 ± 8 | Part 1 (week 1–4): 10 bouts ∗ 1 min (at 89% of PPO pre) | Part1 (week 1–4): 30 min of continuous training (at 58% of PPOpre) | 12 weeks |
| C: 66 ± 8 | Part 2 (week 5–8): 10 bouts ∗ 1 min (at 102% of PPOpre) |
| Part 3 (week 9–12): 10 bouts ∗ 1 min (at 110% of PPOpre) | Part 2 (week 5–8): 40 min of continuous training (at 58% of PPOpre) |
| Each interval: 1 min (at 10% of PPOpre) | Part 3 (week 9–12): 50 min of continuous training (at 58% of PPOpre) |
|
| Currie et al., 2014 | 9 (9)/10 (9, 1) | T: 62 ± 11
C: 68 ± 8 | Part 1 (month 1): 10 bouts ∗ 1 min (at 85% of PPOpre) | Part 1 (month 1): 30 min of continuous training (at 57% PPOpre) | 24 weeks |
| Part 2 (month 2): 10 bouts ∗ 1 min (at 100% of PPOpre) |
| Part 3 (month 3): 10 bouts ∗ 1 min (at 108% of PPOpre) | Part 2 (month 2): 40 min of continuous training (at 57% PPOpre) |
| Part 4 (month 4–6): 10 bouts ∗ 1 min (at 121% of PPOpre) | Part 3 (month–3): 50 min of moderate-intensity exercise (at 57% PPOpre) |
| Each interval: 1 min (at 10% of PPOpre) | Part 4 (month4–6): min of continuous training (at 78% PPOpre) |
|
| Dunford et al., 2021 | 9/11 (Total: 18/2) | Total: 61 ± 7 | 3 bouts ∗ 90 s stairs climbing | 30 min of continuous training (at 60–80% HRpeak) | 12 weeks |
| Each interval: walking 90 s |
|
| Jaureguizar et al., 2016 | 36 (33, 3)/36 (28, 8) | T: 58 ± 11
C: 58 ± 11 | Part 1 (week 1): HIIT: 15 bouts ∗ 20 s (50% of the maximum load reached in the first SRT) | Part 1: MICT: 15 mins (at (VT1) | 8 weeks |
| Each interval: 40 s (10% of the maximum load reached in the first SRT) | Part 2 (2 w): MICT: 20 mins (at VT1) |
| Part 2 (week 2): HIIT: 20 bouts ∗ 20 s (50% of the maximum load reached in the first SRT) | Part 3 (3 w): MICT: 25 mins at (VT1) |
| Each interval: 40 s (10% of the maximum load reached in the first SRT) | Part4 (4 w): MICT: 30 mins at (VT1) |
| Part 3 (week 3): HIIT: 25 bouts ∗ 20 s (50% of the maximum load reached in the first SRT) | Part 5 (5–8 w): MICT: 30 mins at (VT1+10%) |
| Each interval: 40 s (10% of the maximum load reached in the first SRT) |
| Part 4 (week 4): HIIT: 30 bouts ∗ 20 s (50% of the maximum load reached in the first SRT) |
| Each interval: 40 s (10% of the maximum load reached in the first SRT) |
| Part5 (week 5–8): HIIT: 30 bouts ∗ 20 s (50% of the maximum load reached in the second SRT) |
|
| Keteyian et al., 2014 | 36 (33, 3)/36 (28, 8) | T: 58 ± 11
C: 58 ± 11 | 4 bouts of 4 min (at 80–90% of the heart rate reserve) | 30 min of continuous training (at 60% to 80% of heart rate reserve) | 2 weeks |
| Each interval: 3 min (at 60–70% of the heart rate reserve) |
|
| Kim 2020 | 23 (18, 5)/24 (16, 8) | T: 60 ± 11 | 4 bouts ∗ 4 min (at 95–100% of the HRR) | First part: 3 bouts ∗ 8 min (at 85% of the HRR) | 6 weeks |
| C: 62.8 ± 11.9 | Each interval: 3 min (at 60% of the HRR) | Each interval: 3 min (at 40% of the HRR) |
|
| Moholdt et al., 2009 | 28 (24, 4)/31 (24, 7) | T: 60.2 ± 6.9 | 4 bouts ∗ 4 min (at 90% of the HRpeak) | 46 min of continuous training (at least 70% of HRpeak) | 4 weeks |
| C: 62.0 ± 7.6 | Each interval: 3 min (70% of the HRpeak) |
|
| Moholdt et al., 2012 | 30 (25, 5)/59 (49, 10) | T: 56.7 ± 10.4 | 4 bouts ∗ 4 min (at 85–95% HRpeak) | Usual care exercise: 60 min of aerobic exercises | 12 weeks |
| C: 57.7 ± 9.3 | Each interval: 1 min (70% HRpeak) |
|
| Pattyn et al., 2016 | 80 (76, 4)/83 (76, 7) | T: 57.4 ± 8.7 | 4 bouts of 4 min (at 85–95% of the HRpeak) | 37 min of continuous training (at least 70–75% of HRpeak) | 12 weeks |
| C: 59.9 ± 9.2 | Each interval: 3 min (50%–70% of the HRpeak) |
|
| Prado et al., 2016 | 17(14, 3)/18 (14, 4) | T: 56.5 ± 2.7 | 7 bouts ∗ 3 min (at RCP) | 50 min of continuous training (at VAT) | 12 weeks |
| C: 61.3 ± 2.2 | Each interval: 3 min (at VAT) |
|
| Rocco et al., 2012 | 17(14, 3)/20 (15, 5) | T: 56.5 ± 3.0 | 7 bouts ∗ 3 min (at RCP) | 50 min of continuous training (at VAT) | 12 weeks |
| C: 62.3 ± 2.0) | Each interval: 3 min (at VAT) |
|
| Rognmo et al., 2004 | 8(6, 2)/9(8, 1) | T: 62.9 ± 11.2 | 4 bouts ∗ 4 min (at 80–90% oVO2peak (85–95% of HRpeak) | 41 min of continuous training (at 50–60% of VO2 peak) | 10 weeks |
| C: 61.2 ± 7.3 | Each interval: 3 min (at 50–60% of VO2peak) |
|
| Warburton et al., 2005 | 7(NA)/7(NA) | T: 55.9 ± 7 | 15 bouts ∗ 2 min (at 90% of heart rate/VO2reserve (range 85% to 95%)) | 30 min of continuous training (at 65% of heart rate/VO2reserve) | 16 weeks |
| C: 57 ± 8 | Each interval: 2 min (at 40% of heart rate/VO2reserve (range 35% to 45%)) |
|
