Research Article
Relationship between Brain Natriuretic Peptide and Thromboembolic Events in Elderly Patients with Nonvalvular Atrial Fibrillation
Table 1
Comparison of baseline data, primary endpoint events, and adverse events among the three groups.
| | Items | Group A (n = 50) | Group B (n = 65) | Group C (n = 65) | Z or χ2 | |
| | Age (mean ± SD) | 73.0 ± 4.6 | 74.1 ± 5.2 | 74.0 ± 5.0 | 0.693 | 0.501 | | Male (n (%)) | 28 (56.0%) | 38 (58.5%) | 44 (67.7%) | 1.926 | 0.382 | | Smoke (n (%)) | 21 (42.0%) | 27 (41.5%) | 33 (50.8%) | 1.371 | 0.504 | | DM (n (%)) | 17 (34.0%) | 23 (35.4%) | 29 (44.6%) | 1.721 | 0.423 | | CAD (n (%)) | 13 (26.0%) | 17 (26.2%) | 26 (40.0%) | 3.751 | 0.153 | | Previous stroke (n (%)) | 11 (22.0%) | 9 (13.8%) | 14 (21.5%) | 1.693 | 0.429 |
| | Types of AF | | Paroxysmal AF (n (%)) | 43 (86.0%) | 55 (84.6%) | 53 (81.5%) | 1.753 | 0.357 | | Persistent AF (n (%)) | 7 (14.0%) | 10 (15.4%) | 12 (18.5%) | | SBP (mmHg) | 123.5 ± 14.1 | 119.3 ± 15.6 | 121.5 ± 14.4 | 1.152 | 0.318 | | DBP (mmHg) | 69.0 ± 8.7 | 70.2 ± 11.0 | 71.4 ± 10.5 | 0.344 | 0.709 | | BNP (mean ± SD) | 120.8 ± 83.3 | 801.1 ± 276.2 | 2256.1 ± 861.1 | 118.462 | 0.001 | | Cr (mean ± SD) | 72.4 ± 15.3 | 77.5 ± 16.9 | 80.3 ± 40.8 | 1.167 | 0.314 | | HbA1c (mean ± SD) | 6.4 ± 1.2 | 6.3 ± 1.4 | 6.5 ± 1.5 | 0.352 | 0.704 | | TC (mean ± SD) | 4.3 ± 1.1 | 4.4 ± 1.0 | 4.1 ± 1.0 | 0.868 | 0.422 | | TG (mean ± SD) | 1.7 ± 1.0 | 1.5 ± 0.6 | 1.7 ± 1.2 | 1.183 | 0.309 | | HDL (mean ± SD) | 1.1 ± 0.2 | 1.1 ± 0.2 | 1.1 ± 0.3 | 0.051 | 0.950 | | LDL (mean ± SD) | 2.4 ± 0.8 | 2.5 ± 0.8 | 2.3 ± 0.8 | 0.817 | 0.443 | | CHA2DS2-VASc (mean ± SD) | 3.3 ± 1.2 | 3.5 ± 1.1 | 4.1 ± 1.1 | 15.142 | 0.001 | | HAS-BLED (mean ± SD) | 2.1 ± 0.6 | 2.0 ± 0.5 | 2.1 ± 0.5 | 3.575 | 0.167 | | EF (mean ± SD) | 63.6 ± 5.6 | 46.7 ± 7.3 | 39.0 ± 4.6 | 119.893 | 0.001 | | LA (mean ± SD) | 28.1 ± 3.0 | 33.9 ± 4.6 | 41.3 ± 5.5 | 105.031 | 0.001 | | LVEDD (mean ± SD) | 43.84 ± 3.40 | 46.5 ± 4.0 | 54.1 ± 6.0 | 74.430 | 0.001 | | Main endpoint event (n (%)) | 3 (6.0%) | 8 (12.3%) | 17 (26.2%) | 9.556 | 0.008 | | Adverse event (n (%)) | 5 (10.0%) | 18 (27.7%) | 50 (76.9%) | 59.485 | 0.001 |
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Note. SD, standard deviation; DM, diabetes mellitus; CAD, coronary artery disease; AF: atrial fibrillation; SBP: systolic blood pressure; DBP: diastolic blood pressure; Cr, creatinine; HbA1c, hemoglobin A1c; TC, total cholesterol; TG, triglycerides; HDL, high-density lipoprotein; LDL, low-density lipoprotein cholesterol; EF, ejection fraction; LA, left atrial; LVEDD, left ventricular end-diastolic diameter.
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