Mitochondrial respiration, the electron transport chain, and oxidative phosphorylation work in conjunction with each other. This balance can be disturbed under abnormal conditions. Mitochondrial dysfunctions are a common feature of many cardiovascular and metabolic diseases. Initial studies have highlighted the contribution of mitochondrial functions to organ remodeling, heart failure, liver failure, and renal failure.

Recently, it has been demonstrated that metabolic disorders, including metabolic flexibility, metabolic switching, metabolic poise, metabolic plasticity, metabolic reprogramming, metabolic rewiring, metabolic conditioning, metabolic imprinting, and causal metabolism, may participate in acute, subacute, and chronic organ dysfunctions or pathogenesis. Thus, mitochondrial functions and metabolic reprogramming has been considered a progressive condition and the responsible pathophysiological processes have been described. However, many aspects of these remain either incompletely understood or unknown.

This Special Issue aims to collate original research and review articles pertaining to mitochondrial and metabolic disorders in this context, and translation of mechanistic insights towards therapy for cardiovascular diseases.

Potential topics include but are not limited to the following:

• The regulation of mitochondrial structure and function in the progression of cardiovascular disease
• Energy metabolism or metabolic reprogramming of cardiovascular diseases based on clinical big data mining or bioinformatics analysis
• The potential regulatory relationship between new cell death modes and mitochondrial function and energy metabolism
• The regulation mechanism of various cell types or subcellular organelles in the energy supply and metabolism model under the pathological stress of cardiovascular disease