Cardiology Research and Practice

The Roles of Mitochondrial and Metabolic Disorders in Cardiovascular Diseases

Publishing date
01 May 2023
Submission deadline
06 Jan 2023

Lead Editor
Guest Editors

1Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

2Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China

3Yale University, New Haven, USA

This issue is now closed for submissions.

The Roles of Mitochondrial and Metabolic Disorders in Cardiovascular Diseases

This issue is now closed for submissions.


Mitochondrial respiration, the electron transport chain, and oxidative phosphorylation work in conjunction with each other. This balance can be disturbed under abnormal conditions. Mitochondrial dysfunctions are a common feature of many cardiovascular and metabolic diseases. Initial studies have highlighted the contribution of mitochondrial functions to organ remodeling, heart failure, liver failure, and renal failure.

Recently, it has been demonstrated that metabolic disorders, including metabolic flexibility, metabolic switching, metabolic poise, metabolic plasticity, metabolic reprogramming, metabolic rewiring, metabolic conditioning, metabolic imprinting, and causal metabolism, may participate in acute, subacute, and chronic organ dysfunctions or pathogenesis. Thus, mitochondrial functions and metabolic reprogramming has been considered a progressive condition and the responsible pathophysiological processes have been described. However, many aspects of these remain either incompletely understood or unknown.

This Special Issue aims to collate original research and review articles pertaining to mitochondrial and metabolic disorders in this context, and translation of mechanistic insights towards therapy for cardiovascular diseases.

Potential topics include but are not limited to the following:

  • The regulation of mitochondrial structure and function in the progression of cardiovascular disease
  • Energy metabolism or metabolic reprogramming of cardiovascular diseases based on clinical big data mining or bioinformatics analysis
  • The potential regulatory relationship between new cell death modes and mitochondrial function and energy metabolism
  • The regulation mechanism of various cell types or subcellular organelles in the energy supply and metabolism model under the pathological stress of cardiovascular disease
Cardiology Research and Practice
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.