Research Article | Open Access

# Global Dynamics of Infectious Disease with Arbitrary Distributed Infectious Period on Complex Networks

**Academic Editor:**Sanling Yuan

#### Abstract

Most of the current epidemic models assume that the infectious period follows an exponential distribution. However, due to individual heterogeneity and epidemic diversity, these models fail to describe the distribution of infectious periods precisely. We establish a SIS epidemic model with multistaged progression of infectious periods on complex networks, which can be used to characterize arbitrary distributions of infectious periods of the individuals. By using mathematical analysis, the basic reproduction number for the model is derived. We verify that the depends on the average distributions of infection periods for different types of infective individuals, which extend the general theory obtained from the single infectious period epidemic models. It is proved that if , then the disease-free equilibrium is globally asymptotically stable; otherwise the unique endemic equilibrium exists such that it is globally asymptotically attractive. Finally numerical simulations hold for the validity of our theoretical results is given.

#### 1. Introduction

The infectious period of an infective individual means the period during which an infected person has a probability of transmitting the virus to any susceptible host or vector they contact. Note that the infectious period may be associated with the fitness of persons. The influence degrees of infection and rates of disease transmission are varied for individuals with different infectious periods. Every year, some emerging infectious diseases with unknown infectious period are seriously threatening the health of people. There is no doubt that the deficiency of the infectious period’s knowledge results in the difficulty of controlling epidemic. Then, in order to obtain the date of the infectious period of these epidemics in medicine, a large amount of statistics data is necessary. However, it is hard to get the date in the early stage of the disease. Therefore applying mathematical methods to research the effects of infectious period distribution on the infectious diseases spread is significative.

As the SIS compartment model was first proposed by Kermack and McKendrick in 1932 [1], thousands of scientists successively started to study the epidemic propagation by mathematic models [2–4]. In most of their models, infected compartment contains all infected individuals and the proportion of infected individuals who transit into the next state per unit time is a constant . Wearing et al. [5] pointed out that the assumption of exponentially distributed infectious periods always results in underestimating the basic reproductive ratio of an infection from outbreak data. According to the staged progression features of HIV or TB, Lloyd [6] applied gamma distribution to describe the infectious period distribution. However, the distributions of the infectious period of a lot of infectious diseases in the real world may not satisfy exponent or gamma distribution. Then, Feng et al. [7] used integral-differential equations to study the nonexponential distribution of the infectious period. The homogeneous mixing models, they considered, ignore the heterogeneity of contacts of individuals.

The network origins from the well-known six degrees of separation theory. The small-world (SW) property is the most popular feature in complex network theory [8]. The SW networks constitute a mathematical model for social networks that show two types. The first type can be called exponential networks since there is the probability of finding a node with degree different from the average degree which decays exponentially fast for large . The second kind of networks comprises those referred to as scale-free (SF) networks. For these networks, the probability that a given node is connected to other nodes follows a power law of the form , with the remarkable feature that for most real world networks.

With the development of networks research, there have been some researchers studying infectious disease models on networks for decades, such as SIS model proposed by Pastor-Satorras and Vespignani in 2001 [9], SIR model established by Yang et al. in 2007 [10], and SI pattern model introduced by Barthélemy et al. in 2004 [11]. Hence studying the epidemic model with infectious period distribution on networks is necessary and meaningful. However, there is little literature about the infectious period distribution problems based on networks. Zhang et al. in 2011 proposed a susceptible-infected-susceptible staged progression and different infectivity models on different complex networks [12], where the infectious period follows a gamma distribution. Zager and Verghese in 2009 established a discrete differential equation to present an arbitrarily distributed infectious period [13]. Moreover, they studied epidemic thresholds for infections on uncertain networks. However, the former researchers did not analyze the stability of equilibrium theoretically. Therefore, we build continuous-time ordinary differential equations to study an arbitrarily distributed infectious period epidemic model on networks. We extend the scope of previous works in this area to include dynamic analysis results mathematically.

The rest of the paper is organized as follows. In Section 2, we establish an SIS model with an arbitrary distribution of infectious period on complex networks. We compute the basic reproduction number and analyze the globally asymptotic stability of the disease-free equilibrium and the global dynamics of the endemic equilibrium in Section 3. In Section 4, we perform numerical simulations to verify the above theories. Finally, a brief conclusion and discussion will be given in Section 5.

#### 2. The Model

One feature of some diseases is that different patients may have different symptoms. The feature had appeared in some patients of some SIR/SI diseases, such as TB/HIV studied by Guo and Li in 2006 [14]. However, the other feature that different groups may have different infected stage processes is ignored. We propose a modified staged progression model to capture the second feature above. In our model, the infectious period distributions of different groups follow different gamma distributions. The linear combination of different gamma distributions can be transformed into normal distribution, chi-square distribution, exponential distribution, Erlang distribution, or beta distribution [15]. So our model can be transformed into any distributions.

We classify the population as infected and susceptible . Compartment contains those individuals whose infectious period has stages and which are now in the th stage (). Susceptible individuals enter into the first stage after being infected and then gradually progress from this stage to stage . The infected individuals in the stage will be susceptible again.

In contrast to classical compartment models, we consider the whole population and their contacts on networks. Each individual in the community can be regarded as a vertex in the network, and each contact between two individuals is represented as an edge (line) connecting these vertices. The number of edges emanating from a vertex, that is, the number of contacts a person has, is called the degree of the vertex. Therefore, we assume that the population is divided into distinct groups of sizes such that each individual in group has exactly contacts per day. If the whole population size is , then the probability that a uniformly chosen individual has contacts is , which is called the degree distribution of the network. The average degree is .

Let denote the number of susceptible nodes of degree at time . Let be the number of infected nodes whose infectious period has stages and which are now in the th stage of their infection () of degree at time . The transmission sketch is shown in Figure 1.

We make the following basic assumptions about the infectious disease models.(1)Here, we will not incorporate the possibility of individual removal due to birth and death or acquired immunization. That is to say, the total population is a constant.(2)The stages in infectious period can be given by the discrete random variable . The range of values of need not to be finite, but for ease of presentation we assume that can only take values from to . The probability of infected individuals with an infectious period of exactly stages is .(3)The mutants of virus can cause the same individual to suffer different infected stage progression processes if he or she is infected again.(4)In order to analyze the model simply and efficiently, all transmission rates from infected individuals to susceptible individuals are . The duration of infected individuals in compartment th is .(5)In a network with no assortative (i.e., disassortative) then the conditional probability that a given vertex with degree is linked to a vertex with degree by one edge is proportional to , which is independent of its own vertex degree [9], and hence we have . The expectation that any given edge points to an infected vertex becomes .

On the basis of the above assumption, the model of ordinary differential equations with the maximum degree and the maximum infection stages in infectious period is as follows: where , , and . For system (1), since the total population is constant, we can only consider the infected compartments below. For a given degree distribution , the number of the nodes which have the same degree , , is definite, where .

The relative densities of susceptible and infected nodes with an infectious period of stages and which are now in the th stage of degree at time are denoted by and , respectively. Without loss of generality, we set , since it only affects the definition of the time scale of the epidemic transmission.

System (1) can be rewritten as where , , and , and denotes the density of infected nodes of degree at time . Therefore the average infectious period is . Then one can derive that .

#### 3. The Analysis of Model (2)

##### 3.1. Basic Reproduction Number

We will compute the basic reproduction number using the next-generation matrix proposed by van den Driessche and Watmough [16]. For convenience we define and . It is easy to verify that system (2) has a unique disease-free equilibrium . We note that only compartments are involved in the calculation of . In the disease-free state , the rate of appearance of new infections and the rate of transfer of individuals out of the compartments are given by where are the matrices where where is the matrices in which is a block diagonal matrix with blocks and are matrices with entries of 1 on the diagonal and −1 on the first subdiagonal.

Using the concepts of next-generation matrix [16], the reproduction number is given by , that is, the spectral radius of the matrix . We first represent the inverse of by the following matrix: and since is block diagonal with blocks , its inverse will be block diagonal with blocks which is lower triangular matrices with entries of 1.

Setting , we have where are matrices and where where .

Now we are ready to compute the eigenvalues of the matrix . Thus, we obtain that the basic reproduction number which is the largest modulus of the roots of the characteristic equation below

To simplify and compute (11), we have Therefore, we obtain the reproduction number If , we can derive the critical transmission rate from (13), which is

Because the degree distribution of scale-free network is , with in most cases, for which , when the size of network is sufficiently large, then inequality (14) is always satisfied. In other words, the multistaged progression model will prevail on sufficiently large heterogenous networks more easily.

##### 3.2. Global Stability of Disease-Free Equilibrium

In order to study the global stability of the disease-free equilibrium , we first give the following lemma, which guarantees that the densities of each infected class cannot become negative and the sum of the densities of infective individuals with the same degree cannot be greater than unity.

Let . Since , we study system (2) for (, ).

Lemma 1 (see [17]). *The set is positively invariant for the system (2).*

*Proof. *We will show that if , then for all . Denote
Let the outer normals be denoted by and .

For arbitrary compact set , Yorke had proved that is invariant for , if, at each point in (the boundary of ), the vector is tangent or pointing to the set [18]. We can easily apply the result here, since is an -dimensional rectangle. Through Yorke’s result, it is not difficult to obtain that
Hence, any solution that starts in stays inside .

By letting , where , and , in which is a column vector with rows and , , , , , and , . In the following, we use the method introduced in [19] to demonstrate the global behavior of the system (2). Then, (2) can be rewritten as a compact vector form where is the linear part of , is the nonlinear part of , and .

Denote , where for are the eigenvalues of , and Re represents the real part of the eigenvalues.

*Remark 2. *Consider ; .

To obtain the global stability of the disease-free equilibrium , we need the following lemma.

Lemma 3 (see [20]). *Consider the system
**
where is an matrix and is continuously differentiable in a region . Assume that *(1)*the compact convex set is positively invariant with respect to the system (18), and ;*(2)*;*(3)*there exist and a (real) eigenvector of such that for all ;*(4)* for all ;*(5)* is the largest positively invariant set (for (18)) contained in .**Then either is globally asymptotically stable in or for any the solution of (18) satisfies , where , independent of the initial value . Moreover, there exists a constant solution of (18), , .*

We will confirm that system (17) satisfies all the hypotheses of Lemma 3. Condition of Lemma 3 is satisfied by letting . For condition , notice that is irreducible and whenever , and then there exists an eigenvector of and the associated eigenvalue is . If we let , for , we then obtain . Therefore for all , where we set . Conditions and are clearly satisfied.

To verify , we set. If , then . But since each term of the sum is nonnegative, for and for , and then we have . Hence if , then . Therefore, the only invariant set with respect to (17) contained in is , and so condition is satisfied.

Hence all the hypotheses of Lemma 3 are satisfied. Then either (the solution is globally asymptotically stable in ) or , and there exists a constant solution of (17), ,.

Theorem 4. *If , then the solution (i.e., disease-free equilibrium ) of the system (17) is globally asymptotically stable in ; otherwise , and there exists a constant solution .*

##### 3.3. Global Attractivity of Endemic Equilibrium

In the following, we will compute the value of the unique endemic equilibrium of the system (1), and we will use the method in [17] to ascertain global attractivity of the nonzero solution (i.e., endemic equilibrium).

For system (1), if , we can derive the endemic equilibrium , where , , and , for , , , in which , , and is the total number of nodes and keeps a constant, . Then we can give the following theorem.

Theorem 5. *If , there exists a unique endemic solution of (17) such that is globally attractive in .*

*Proof. *We will prove that is globally attractive in , where ), and . We define the following functions: and for , where , . and are continuous and right-hand derivative exists along solutions of (17). We let and be a solution of (17), and we may assume that , , for a given and for sufficiently small . Then,
where is defined as . If , from (17) we have
or if , we have

According to the definition of , we have
Then if , we obtain
or
and since and , we conclude that . Therefore, if , .

Similarly, we can testify if , and if . If , then . Denote
Both and are continuous and nonnegative for . Notice that
Letting , , then we have and . According to the LaSalle invariant set principle, any solution in will approach . And . But if , by Lemma 3 we know that . Then we conclude that any solution of (17), such that , satisfies , so is globally attractive in .

#### 4. Numerical Simulations and Sensitivity Analysis

In this section, we first perform some sensitivity analysis of the basic reproduction number in terms of the model parameters on BA scale-free networks. Here , , , .

From Figure 2, we can see the influence of transmission rate and the average infectious period . In particular, the influence of the diversity of the infectious periods is presented in Figure 2; the longer the infectious periods that the individuals have, the greater the basic reproduction number is. When is fixed, is a monotone increasing with the value of and is a monotone increasing function of when is fixed. At the same time, is linear function in terms of and . The basic reproduction number will increase with the increase of average infectious period and transmission rate.

We simulate the time series of total number of infected nodes on BA scale-free networks in Figure 3, which corresponds to and , respectively. We can see that if , the disease will disappear quickly; otherwise when the disease will persist in the system. So it is verified that is the threshold for the dynamics of disease.

**(a)**

**(b)**

In Figure 4, the blue line represents , (), and , and the red line represents , , , , , and the rest of . The mean of infectious periods for red or blue line is . Even though the final sizes for the same are the same, no matter or , the cumulative numbers of infected individuals with different distributions are different.

**(a)**

**(b)**

#### 5. Conclusion and Discussion

In this paper, we establish an SIS epidemic spreading model with an arbitrary distribution of infectious period and take network structure into consideration. The disease-free equilibrium is globally asymptotically stable when . In the other case, there exists a unique endemic equilibrium such that it is globally attractive. Some numerical simulations are also performed to verify our theoretical results.

It is well known that, on a normal network, the basic reproduction number depends on the degree distribution, transmission rate, and recovery rate. However, when the characteristics of different nodes have a larger difference, the will depend on the distribution of these characteristics, such as the infectious period. From the equation of epidemic threshold, we have shown that the basic reproduction number depends on the heterogeneity of the social networks and the diversity of the infectious periods of the individuals. And we obtain that the heterogeneity of the network and the long infectious period resulting in the infection deteriorate into endemic more easily.

By modifying the staged progression model, we propose the multistaged progression model which contains several different gamma distributions. The linear combination of gamma distributions with different parameters can describe an arbitrarily distributed distribution of the infectious period. We find that the number of stable infected individuals for different infectious periods is the same; however, the cumulative numbers of the infected individuals are different corresponding to the different infectious period distributions. And numerical simulations show that different infectious period distributions can lead to different transmission processes. Hence our model can characterize the diversity of the infectious period during the disease transmission on complex networks more realistic.

#### Conflict of Interests

The authors declare that there is no conflict of interests regarding the publication of this paper.

#### Acknowledgments

This work is supported by the National Natural Science Foundation of China under Grant nos. 11331009, 11171314, 11147015, 11301490, 11301491, and 11101251, the Specialized Research Fund for the Doctoral Program of Higher Education (preferential development) no. 20121420130001, and the Youth Science Fund of Shanxi Province (2012021002-1).

#### References

- W. O. Kermack and A. G. McKendrick, “Contributions to the mathematical theory of epidemics,”
*Proceedings of the Royal Society of London A*, vol. 138, no. 834, pp. 55–83, 1932. View at: Google Scholar - R. M. Anderson and R. M. C. May,
*Infectious Diseases of Humans*, Oxford University Press, Oxford, UK, 1991. - J. D. Murray,
*Mathematical Biology I: An I ntroduction*, Springer, New York, NY, USA, 2002. View at: MathSciNet - M. J. Keeling and P. Rohani,
*Modeling Infectious Diseases in Humans and Animals*, Princeton University Press, Princeton, NJ, USA, 2008. View at: MathSciNet - H. J. Wearing, P. Rohani, and M. J. Keeling, “Appropriate models for the management of infectious diseases,”
*PLoS Medicine*, vol. 2, no. 7, Article ID e174, 2005. View at: Publisher Site | Google Scholar - A. L. Lloyd, “Realistic distributions of infectious periods in epidemic models: changing patterns of persistence and dynamics,”
*Theoretical Population Biology*, vol. 60, no. 1, pp. 59–71, 2001. View at: Publisher Site | Google Scholar - Z. Feng, D. Xu, and H. Zhao, “Epidemiological models with non-exponentially distributed disease stages and applications to disease control,”
*Bulletin of Mathematical Biology*, vol. 69, no. 5, pp. 1511–1536, 2007. View at: Publisher Site | Google Scholar | Zentralblatt MATH | MathSciNet - S. H. Strogatz, “Exploring complex networks,”
*Nature*, vol. 410, no. 6825, pp. 268–276, 2001. View at: Publisher Site | Google Scholar - R. Pastor-Satorras and A. Vespignani, “Epidemic spreading in scale-free networks,”
*Physical Review Letters*, vol. 86, no. 14, pp. 3200–3203, 2001. View at: Publisher Site | Google Scholar - R. Yang, B.-H. Wang, J. Ren et al., “Epidemic spreading on heterogeneous networks with identical infectivity,”
*Physics Letters A*, vol. 364, no. 3-4, pp. 189–193, 2007. View at: Publisher Site | Google Scholar - M. Barthélemy, A. Barrat, R. Pastor-Satorras, and A. Vespignani, “Velocity and hierarchical spread of epidemic outbreaks in scale-free networks,”
*Physical Review Letters*, vol. 92, no. 17, Article ID 178701, 2004. View at: Publisher Site | Google Scholar - H. F. Zhang, M. Small, and X. C. Fu, “Staged progression model for epidemic spread on homogeneous and heterogeneous networks,”
*Journal of Systems Science & Complexity*, vol. 24, no. 4, pp. 619–630, 2011. View at: Publisher Site | Google Scholar | MathSciNet - L. Zager and G. Verghese, “Epidemic thresholds for infections in uncertain networks,”
*Complexity*, vol. 14, no. 4, pp. 12–25, 2009. View at: Publisher Site | Google Scholar | MathSciNet - H. B. Guo and M. Y. Li, “Global dynamics of a staged progression model for infectious diseases,”
*Mathematical Biosciences and Engineering*, vol. 3, no. 3, pp. 513–525, 2006. View at: Publisher Site | Google Scholar | MathSciNet - L. M. Leemis, “Relationships among common univariate distributions,”
*The American Statistician*, vol. 40, no. 2, pp. 143–146, 1986. View at: Publisher Site | Google Scholar | MathSciNet - P. van den Driessche and J. Watmough, “Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission,”
*Mathematical Biosciences*, vol. 180, no. 1, pp. 29–48, 2002. View at: Publisher Site | Google Scholar | MathSciNet - Y. Wang, Z. Jin, Z. Yang, Z. A. Zhang, and G. Sun, “Global analysis of an SIS model with an infective vector on complex networks,”
*Nonlinear Analysis: Real World Applications*, vol. 13, no. 2, pp. 543–557, 2012. View at: Publisher Site | Google Scholar | MathSciNet - J. A. Yorke, “Invariance for ordinary differential equations,”
*Mathematical Systems Theory*, vol. 1, no. 4, pp. 353–372, 1967. View at: Publisher Site | Google Scholar | MathSciNet - A. d'Onofrio, “A note on the global behaviour of the network-based SIS epidemic model,”
*Nonlinear Analysis: Real World Applications*, vol. 9, no. 4, pp. 1567–1572, 2008. View at: Publisher Site | Google Scholar | MathSciNet - A. Lajmanovich and J. A. Yorke, “A deterministic model for gonorrhea in a nonhomogeneous population,”
*Mathematical Biosciences*, vol. 28, no. 3, pp. 221–236, 1976. View at: Publisher Site | Google Scholar | MathSciNet

#### Copyright

Copyright © 2014 Xiaoguang Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.