A Multiregion Discrete-Time Epidemic Model of Mycobacterium tuberculosis Infections: An Optimal Control Approach

Table 1

Parameter values.

Symbol	Description	Value	Source
D	Natural death rate	1/76.45	[30]
	Rate at which individuals leave		[12]
	Proportion of individuals going to compartment I	0.05	[33]
	Rate of endogenous reactivation for persistent latent infections		[36]
	Rate of endogenous reactivation for treated individuals		[12]
	Factor reducing the risk of infection as a result of acquired immunity to a previous infection for persistent latent individuals	0.25	[12]
	Factor reducing the risk of infection as a result of acquired immunity to a previous infection for treated individuals	0.25	[12]
	Rate of recovery under treatment of active TB		[12]
	Rate of recovery of early latent individuals under postexposure interventions		[12]
	Rate of recovery of persistent latent individuals under postexposure interventions		[12]
N	Total population	10000; 20000; 30000	Estimated
T	Total simulation duration