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Disease Markers
Volume 11, Issue 2-3, Pages 125-130

Parental HLA Sharing, Feto-Maternal Compatibility and Neonatal Birthweight in Families With a History of Recurrent Spontaneous Abortion

D. C. Kilpatrick and W. A. Liston

Department of Transfusion Medicine alld Obstetrics alld Gynecology, The Royal Infirmary, Edinburgh, Scotland, UK

Received 9 February 1993

Copyright © 1993 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The mean birthweight of babies eventually born to couples with a history of recurrent spontaneous abortion (RSA) is allegedly lower if the parents have a high degree of HLA antigen sharing (Reznikoff-Etievant et al., 1991), but this relationship has not been independently confirmed. We have re-investigated this question by analysing data from 36 families. In 22 instances, we were able to relate birthweight directly to feto-maternal HLA compatibility for the first time in such families. We were unable to confirm any appreciable influence of paternal or feto-maternal HLA sharing on birthweight or placental weight and conclude that RSA families do not differ markedly from normal families in this respect.