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Disease Markers
Volume 12, Issue 4, Pages 253-259

Cathepsin-D And Tnf-α in Bladder Cancer

T. Salman,1 O. El-Ahmady,1 M. El-Shafee,1 Sh. Omar,2 and I. Salman3

1Tumor Marker Oncology Research Centre, AI-Azhar University, NCI, Cairo, Egypt
2NCI, Cairo University, Cairo, Egypt
3Urology Department, Faculty of Medicine, El-Menofia University, Egypt

Received 30 October 1995

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In a study of 34 normal healthy controls, 35 patients with urinary tract bilharziasis and 93 bladder cancer patients (62 of them are operable cases and 31 are non-operable ones), serum tumor necrosis factor alpha (TNF-α) and cytosolic Cathepsin-D were estimated. Though both potential markers were elevated in bladder cancer patients, neither Cathepsin-D nor TNF-α showed associations of prognostic value since there were no positive correlations with tumor stages, grades or association of tumors with bilharzia) ova or lymph node involvement.