Disease Markers

Disease Markers / 1996 / Article

Open Access

Volume 12 |Article ID 814192 | https://doi.org/10.1155/1996/814192

F. Gloria-Bottini, M. Nicotra, N. Lucarini, P. Borgiani, M. La Torre, A. Amante, A. Gimelfarb, E. Bottini, "Phosphotyrosine-Protein-Phosphatases and Human Reproduction: An Association between Low Molecular Weight Acid Phosphatase (ACPl) and Spontaneous Abortion", Disease Markers, vol. 12, Article ID 814192, 9 pages, 1996. https://doi.org/10.1155/1996/814192

Phosphotyrosine-Protein-Phosphatases and Human Reproduction: An Association between Low Molecular Weight Acid Phosphatase (ACPl) and Spontaneous Abortion

Received01 Nov 1994


ACP1 (low molecular weight acid phosphatase) genetic polymorphism has been studied in 173 women with a history of two or more consecutive spontaneous abortions and in 1508 control subjects, including 482 normal pregnant women. The proportion of carriers of ACP1 *C allele (* A/ *C, *B/*C) in women with a history of repeated spontaneous abortion is lower than in normal pregnant women and other control groups, Women with repeated spontaneous abortion show a specific decrease of ACPI S isoform concentration as compared to normal pregnant women, The other component of ACP I activity, the F isoform, does not show a significant difference between the two groups. The data suggest that women with ACP1 genotypes showing a high concentration of S isoform are relatively 'protected' against spontaneous abortion, Preliminary analysis of a sample of 352 normal puerperae along with their newborn babies supports this hypothesis,

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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