F. Gloria-Bottini, M. Nicotra, N. Lucarini, P. Borgiani, M. La Torre, A. Amante, A. Gimelfarb, E. Bottini, "Phosphotyrosine-Protein-Phosphatases and Human Reproduction: An Association between Low Molecular Weight Acid Phosphatase (ACPl) and Spontaneous Abortion", Disease Markers, vol. 12, Article ID 814192, 9 pages, 1996. https://doi.org/10.1155/1996/814192
Phosphotyrosine-Protein-Phosphatases and Human Reproduction: An Association between Low Molecular Weight Acid Phosphatase (ACPl) and Spontaneous Abortion
ACP1 (low molecular weight acid phosphatase) genetic polymorphism has been studied in 173 women with a history of two or more consecutive spontaneous abortions and in 1508 control subjects, including 482 normal pregnant women. The proportion of carriers of ACP1 *C allele (* A/ *C, *B/*C) in women with a history of repeated spontaneous abortion is lower than in normal pregnant women and other control groups, Women with repeated spontaneous abortion show a specific decrease of ACPI S isoform concentration as compared to normal pregnant women, The other component of ACP I activity, the F isoform, does not show a significant difference between the two groups. The data suggest that women with ACP1 genotypes showing a high concentration of S isoform are relatively 'protected' against spontaneous abortion, Preliminary analysis of a sample of 352 normal puerperae along with their newborn babies supports this hypothesis,
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