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Disease Markers
Volume 13, Issue 4, Pages 227-235
http://dx.doi.org/10.1155/1998/235151

Analysis of the Association of A Heat Shock Protein70-1 Gene Promoter Polymorphism With Myocardial Infarction and Coronary Risk Traits

M.K. Bolla,1 G.J. Miller,2 D.M. Yellon,3 A. Evans,4 G. Luc,5 J.P. Cambou,6 D. Arveiler,7 F. Cambien,8 D.S. Latchman,9 S.E. Humphries,1 and I.N.M. Day1

1Cardiovascular Genetics, Department of Medicine, University College London Medical School, The Rayne Institute, 5 University Street, London WCIE 6JJ, UK
2MRC Epidemiology and Medical Care Unit, Wolfson Institute of Prevelllive Medicine, The Medical College of ST. Bartholomew's Hospital, Charterhouse Square, London EC1M 6BQ, UK
3Division of Cardiology, Hatter Institute for Cardiovascular Studies, University College Hospital, Grafton Way, London WC1, UK
4MONICA project, Belfast, UK
5MONICA project, Lille, France
6MONICA project, Toulouse, France
7MONICA project, Strasbourg, France
8INSERM, SC7-17, rue du Fer à Moulin, 75005 Paris, France
9Department of Molecular Pathology, Windeyer Building, Cleveland Street, London WCIP 6DB, UK

Received 21 July 1997

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Heat shock proteins (HSP) are induced during coronary ischaemia, and abnormal expression of one HSP gene may cause hypertension in rats, We examined association of a promoter polymorphism in the major stress-inducible hsp70 gene (hsp70-1 or HSP70A1) on chromosome 6 (p21.3) with coronary disease traits, This C→A base substitution (AAACCCC) is at nucleotide position -110 in the heat shock transcription factor binding site (heat shock element, HSE). The first study sample (ECTIM), recruited from Belfast and three centres in France, consisted of 578 myocardial infarction cases and 698 agematched controls. The frequency of the A-110 allele was 0.381 (95% CI=0.35-0.41) and 0.384 (95% CI=0.36-0.41) in cases and controls respectively, Homozygotes for the rarer A-110 allele had a higher BMI (27.3 kg/m2±3.9) compared with homozygotes for the common C-110 allele (26.3 kg/m2±3.3), The rarer homozygotes were shorter and heavier than the common homozygotes. A follow-up study involved 1431 healthy, middle aged men from the UK (NPHSII group). The frequency of the A-110allele was 0.385 (95% CI=0.37 -0.40), and there was no association of genotype with BMI. Thus there appears to be no strong association of the Hsp70-1 promoter polymorphism with risk of myocardial infarction, BMI or any coronary disease traits analysed here.