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Disease Markers
Volume 14 (1998), Issue 3, Pages 135-141
http://dx.doi.org/10.1155/1998/705857

Implication of HLA-DMA Alleles in Corsican IDDM

P. Cucchi-Mouillot,1,4 S. Lai,2 C. Carcassi,2 P. Sorba,3 M. Stuart-Simoni,3 J.-P. Amoros,3 B. Genetet,4 D. Haras,1 and L. Contu2

1CEVAREN, Université de Corse, Campus Grossetti, 20250 Corte, France
2Cattedra di Genetica Medica, Università di Cagliari, via San Giorgio 12, 09124 Cagliari, Italy
3Centre Hospitalier Général d’Ajaccio, 20000 Ajaccio, France
4Groupe Universitaire de Recherche en Immunologie et Immunopathologie, EA 1257, Université Rennes I, 2 av. du AR. Léon Bernard, 35 043 Rennes, France

Received 9 December 1999; Accepted 9 December 1999

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The HLA-DM molecule catalyses the CLIP/antigen peptide exchange in the classical class II peptide-binding groove. As such, DM is an antigen presentation regulator and may be linked to autoimmune diseases. Using PCR derived methods, a relationship was revealed between DM gene polymorphism and IDDM, in a Corsican population. The DMA*0101 allele was observed to confer a significant predisposition to this autoimmune disease while the DMA*0102 allele protected significantly. Experiments examining polymorphism of the HLA-DRB1 gene established that these relationships are not a consequence of linkage disequilibrium with HLA-DRB1 alleles implicated in this pathology. The study of the DMA gene could therefore be an additional tool for early IDDM diagnosis in the Corsican population.