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Disease Markers
Volume 17, Issue 2, Pages 59-65

Analysis of Expression Patterns: The Scope of the Problem, the Problem of Scope

Yidong Chen,1 Zohar Yakhini,2 Amir Ben-Dor,2 Edward Dougherty,3 Jeffrey M. Trent,1 and Michael Bittner1

1Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
2Chemical and Biological Systems Department, Agilent Laboratories, Palo Alto, CA 94304, USA
3Department of Electrical Engineering, Texas A & M University, College Station, TX 77843, USA

Received 20 September 2001; Accepted 20 September 2001

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Studies of the expression patterns of many genes simultaneously lead to the observation that even in closely related pathologies, there are numerous genes that are differentially expressed in consistent patterns correlated to each sample type. The early uses of the enabling technology, microarrays, was focused on gathering mechanistic biological insights. The early findings now pose another clear challenge, finding ways to effectively use this kind of information to develop diagnostics.