Disease Markers

Disease Markers / 2004 / Article
Special Issue

Functional Imaging of Early Markers of Disease. Part 2

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Open Access

Volume 19 |Article ID 460797 | https://doi.org/10.1155/2004/460797

Natasha Shah, Albert E. Cerussi, Dorota Jakubowski, David Hsiang, John Butler, Bruce J. Tromberg, "The Role of Diffuse Optical Spectroscopy in the Clinical Management of Breast Cancer", Disease Markers, vol. 19, Article ID 460797, 11 pages, 2004. https://doi.org/10.1155/2004/460797

The Role of Diffuse Optical Spectroscopy in the Clinical Management of Breast Cancer

Received13 Apr 2004
Accepted13 Apr 2004


Diffuse optical spectroscopy (DOS) of breast tissue provides quantitative, functional information based on optical absorption and scattering properties that cannot be obtained with other radiographic methods. DOS-measured absorption spectra are used to determine the tissue concentrations of deoxyhemoglobin (Hb-R), oxyhemoglobin (Hb-O2), lipid, and water (H2O), as well as to provide an index of tissue hemoglobin oxygen saturation (StO2). Tissue-scattering spectra provide insight into epithelial, collagen, and lipid contributions to breast density. Clinical studies of women with malignant tumors show that DOS is sensitive to processes such as increased tissue vascularization, hypoxia, and edema. In studies of healthy women, DOS detects variations in breast physiology associated with menopausal status, menstrual cycle changes, and hormone replacement. Current research involves using DOS to monitor tumor response to therapy and the co-registration of DOS with magnetic resonance imaging. By correlating DOS-derived parameters with lesion pathology and specific molecular markers, we anticipate that composite “tissue optical indices” can be developed that non-invasively characterize both tumor and normal breast-tissue function.

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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