Fatma Savran Oguz, Lale Ocal, Ali Sarper Diler, Hilmi Ozkul, Faruk Asicioglu, Esen Kasapoglu, Gokay Bozkurt, Meral Konice, Mahmut Carin, "HLA B-27 Subtypes in Turkish Patients with Spondyloarthropathy and Healthy Controls", Disease Markers, vol. 20, Article ID 565270, 4 pages, 2004. https://doi.org/10.1155/2004/565270
HLA B-27 Subtypes in Turkish Patients with Spondyloarthropathy and Healthy Controls
The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group Criteria, and 55 HLA-B27 positive healthy controls. The frequency of HLA-B∗27 was 2.6% in the Turkish population, and B∗2705 was the predominant allele among patients with SpA. The difference was mainly between male patients and male controls The proportion of B∗2705 among B27-positive patients and controls was significantly different (P = 0.02). Our study supports other reports from different populations which showed that B∗2705 and B∗2702 were more frequent in Caucasian patients with SpA.
Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.