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Disease Markers
Volume 21, Issue 1, Pages 21-27

α-SM Actin Expression as Prognostic Indicator in IgA Nephropathy (Berger’s Disease)

M. T. Pastorello,1 R. S. Costa,1 R. C. Ravinal,1 M. Coimbra,2 M.A dos Reis,3 and M. Dantas4

1Deptment of Pathology, Medical School of Ribeirão Preto, University of São Paulo, Brazil
2Deptment of Physiology, Medical School of Ribeirão Preto, University of São Paulo, Brazil
3Deptment of General Pathology, Medical School of Triângulo Mineiro, Uberaba, Brazil
4Deptment of Clinical Medicine, Medical School of Ribeirão Preto, University of São Paulo, Brazil

Received 23 February 2005; Accepted 23 February 2005

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Recent studies have demonstrated that α-Smooth Muscle actin expression in glomerular and tubulointerstitial compartments of renal tissue could represent a prognostic marker in several renal diseases. Our objective was to identify the prognostic value of α-SM actin actin expression on the evolution of renal damage in Primary IgA nephropathy (Berger’s Disease). 43 patients followed up from 1988 to 1999 at the University Hospital, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil, was studied. Clinical-laboratory data were obtained from the medical records of the patients using a protocol containing name, race, gender, origin, profession, age at clinical presentation of the disease and personal and family history. The parameters assessed in the approach to IgA nephropathy were serum creatinine, creatinine clearance, serum albumin, total serum protein, 24 hours proteinuria, glycaemia, serum sodium, potassium, calcium and phosphorus ions, analysis of urinary sediment, serum complement profile, blood count, and renal biopsy. Morphological evaluation was performed by renal biopsy using common light and immunofluorescence microscopy. Immunohistochemical studies were performed using a murine monoclonal antibody to α-SM actin. Our data showed that α-SM actin expression in the glomerular and tubulointerstitial compartments are not correlated with unfavorable clinical course of primary IgA nephropathy.