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Disease Markers
Volume 21, Issue 2, Pages 71-74

Age-Dependent Decrease in Serum Transforming Growth Factor (TGF)-Beta 1 in Healthy Japanese Individuals; Population Study of Serum TGF-Beta 1 Level in Japanese

Yoshihiro Okamoto,1 Yoshimitsu Gotoh,2 Osamu Uemura,2 Soichi Tanaka,3 Tsunesaburo Ando,2 and Mikio Nishida1

1Division of Health Care Pharmacy, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan
2Department of Pediatrics, Nagoya Daini Red Cross Hospital, 2-9 Myoken-cho, Showa-ku, Nagoya 466-8650, Japan
3Department of Pediatrics, Komaki City Hospital, 1-20 Jyobushi, Komaki, Aich, 485-8520, Japan

Received 24 May 2005; Accepted 24 May 2005

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Transforming growth factor-beta1 (TGF-β1), a multi-functional cytokine, is involved in regulating a variety of cellular activities and the serum/plasma TGF-β1 level is altered with various diseases. However, most published reports have described adult patients, and so we investigated the clinical significance of serum TGF-β1 level in pediatric patients. The diagnostic application of the measurement of serum TGF-β1 level depends critically on the control value, however, there is no information on the control value of serum TGF-β1 for children.

In the present study, we determined the serum TGF-β1 level of healthy Japanese children as a control value with enzyme-linked immunosorbent assay (ELISA). The serum TGF-β1 level of children (0–14 years old) was significantly higher than that of adults (over 15 years old) (p < 0.01). Thus, it is recommended that when the serum TGF-β1 levels of patients are evaluated, they should be compared with those of age-matched controls.