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Disease Markers
Volume 23, Issue 4, Pages 273-281

HPV Detection Methods

Antoinette A. T. P. Brink, Peter J. F. Snijders, and Chris J. L. M. Meijer

VU University medical center, Department of Pathology, Section Molecular Pathology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands

Received 20 June 2007; Accepted 20 June 2007

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Given the causal relation between a persistent high-risk human papillomavirus (hrHPV) infection and the development of high-grade cervical intraepithelial neoplasia (CIN) and cervical cancer, hrHPV testing has been advocated in addition to cytology for the detection of clinically relevant cervical lesions. HrHPV testing is thought to improve cervical screening algorithms, the management of women with cytologically equivocal smears, and the management of women treated for high grade CIN. In this chapter we discuss different methods for HPV detection and genotyping and their respective applications.