Disease Markers

Disease Markers / 2007 / Article
Special Issue

Human Papillomaviruses and Cervical Cancer

View this Special Issue

Open Access

Volume 23 |Article ID 245146 | https://doi.org/10.1155/2007/245146

Joeli A. Brinkman, Sarah H. Hughes, Pamela Stone, Angela S. Caffrey, Laila I. Muderspach, Lynda D. Roman, Jeffrey S. Weber, W. Martin Kast, "Therapeutic Vaccination for HPV Induced Cervical Cancers", Disease Markers, vol. 23, Article ID 245146, 16 pages, 2007. https://doi.org/10.1155/2007/245146

Therapeutic Vaccination for HPV Induced Cervical Cancers

Received20 Jun 2007
Accepted20 Jun 2007


Cervical Cancer is the second leading cause of cancer–related deaths in women worldwide and is associated with Human Papillomavirus (HPV) infection, creating a unique opportunity to treat cervical cancer through anti-viral vaccination. Although a prophylactic vaccine may be available within a year, millions of women, already infected, will continue to suffer from HPV-related disease, emphasizing the need to develop therapeutic vaccination strategies. A majority of clinical trials examining therapeutic vaccination have shown limited efficacy due to examining patients with more advanced-stage cancer who tend to have decreased immune function. Current trends in clinical trials with therapeutic agents examine patients with pre-invasive lesions in order to prevent invasive cervical cancer. However, longer follow-up is necessary to correlate immune responses to lesion regression. Meanwhile, preclinical studies in this field include further exploration of peptide or protein vaccination, and the delivery of HPV antigens in DNA-based vaccines or in viral vectors. As long as pre-clinical studies continue to advance, the prospect of therapeutic vaccination to treat existing lesions seem good in the near future. Positive consequences of therapeutic vaccination would include less disfiguring treatment options and fewer instances of recurrent or progressive lesions leading to a reduction in cervical cancer incidence.

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

 PDF Download Citation Citation
 Order printed copiesOrder

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.