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Disease Markers
Volume 23 (2007), Issue 3, Pages 189-196
http://dx.doi.org/10.1155/2007/281727

Matrix Metalloproteinase Expression Patterns in Luminal A Type Breast Carcinomas

J. Decock,1 W. Hendrickx,1,2 M. Drijkoningen,2,3 H. Wildiers,1,2 P. Neven,2 A. Smeets,2 and R. Paridaens1,2

1Laboratory for Experimental Oncology (LEO), Department of General Medical Oncology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
2Multidisciplinary Breast Center, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
3Pathology Department, University Hospital Sint Rafaël, Minderbroedersstraat 12, 3000 Leuven, Belgium

Received 13 April 2007; Accepted 13 April 2007

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective: Aberrant expression of individual matrix metalloproteinases has been associated with poor prognosis in various human carcinomas. The current study aimed at defining an RNA expression profile of various MMPs in breast cancer and correlating their expression with clinicopathological parameters.

Methods: The RNA expression patterns of 6 MMPs (MMP2, MMP8, MMP9, MMP10, MMP11, MMP13) were determined in 25 breast carcinomas using quantitative RT-PCR and correlated with clinicopathological parameters, including menopausal status, tumor size and grade, and lymph node involvement.

Results: We observed high MMP2 levels more frequently in premenopausal than in postmenopausal women (p = 0.02). Analysis of luminal A type invasive ductal carcinomas (19/25), revealed an even stronger association of MMP2 with menopausal status (p = 0.005). Within this subgroup, we also found a correlation between MMP11 and menopausal status (p = 0.02). No correlation was found between MMP expressions and other clinicopathological parameters. In co-expression analyses MMP2-MMP10 and MMP8-MMP9 showed a weak correlation of their expression.

Conclusions: Although this is a pilot study, our findings indicate that luminal A invasive ductal carcinomas commonly express high MMP2 and MMP11 levels in premenopausal breast cancer patients and suggest a co-regulation of MMP2-MMP10 and MMP8-MMP9.