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Disease Markers
Volume 23, Issue 3, Pages 139-145

Two Insulin Gene Single Nucleotide Polymorphisms Associated with Type 1 Diabetes Risk in the Finnish and Swedish Populations

Antti-Pekka Laine,1 Hanna Holmberg,3 Anita Nilsson,4 Eva Örtqvist,5 Minna Kiviniemi,1 Outi Vaarala,3,6 Hans K. Åkerblom,7 Olli Simell,2 Mikael Knip,7,8 Johnny Ludvigsson,3 Sten-A. Ivarsson,4 Karin Larsson,4 Åke Lernmark,4 and Jorma Ilonen1,9

1Immunogenetics Laboratory, University of Turku, Turku, Finland
2Department of Paediatrics, University of Turku, Turku, Finland
3Department of Molecular and Clinical Medicine, Linköping University, Linköping, Sweden
4Department of Endocrinology and Paediatrics, University Hospital Malmö, University of Lund, Lund, Sweden
5Astrid Lindgren’s Children Hospital, Karolinska Hospital, Stockholm, Sweden
6Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
7Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
8Department of Pediatrics, Tampere University Hospital, Tampere, Finland
9Department of Clinical Microbiology, University of Kuopio, Kuopio, Finland

Received 13 April 2007; Accepted 13 April 2007

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [11 citations]

The following is the list of published articles that have cited the current article.

  • Johanna Lempainen, Outi Vaarala, Miia Mäkelä, Riitta Veijola, Olli Simell, Mikael Knip, Robert Hermann, and Jorma Ilonen, “Interplay between PTPN22 C1858T polymorphism and cow's milk formula exposure in type 1 diabetes,” Journal of Autoimmunity, vol. 33, no. 2, pp. 155–164, 2009. View at Publisher · View at Google Scholar
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  • Elena Sukarova-Angelovska, Aleksandra Jovanovska, Mikael Knip, Kati Lipponen, Mirjana Kocova, and Jorma Ilonen, “HLA-DR-DQ haplotypes and type 1 diabetes in Macedonia,” Human Immunology, vol. 70, no. 6, pp. 461–463, 2009. View at Publisher · View at Google Scholar
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  • Mikael Knip, Jorma Ilonen, Johanna Lempainen, Olli Simell, Riitta Veijola, and Robert Hermann, “Effect of the PTPN22 and INS Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of beta-Cell Autoimmunity,” Diabetes, vol. 61, no. 4, pp. 963–966, 2012. View at Publisher · View at Google Scholar
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  • Jorma Ilonen, Anna Hammais, Antti-Pekka Laine, Johanna Lempainen, Outi Vaarala, Riitta Veijola, Olli Simell, and Mikael Knip, “Patterns of beta-Cell Autoantibody Appearance and Genetic Associations During the First Years of Life,” Diabetes, vol. 62, no. 10, pp. 3636–3640, 2013. View at Publisher · View at Google Scholar
  • Na Zhang, Weihuang Huang, Fang Dong, Yang Liu, Baohuan Zhang, Lipeng Jing, Man Wang, Guang Yang, and Chunxia Jing, “Insulin gene VNTR polymorphisms −2221MspI and −23HphI are associated with type 1 diabetes and latent autoimmune diabetes in adults: a meta-analysis,” Acta Diabetologica, 2015. View at Publisher · View at Google Scholar
  • Simon E. Regnell, and Åke Lernmark, “Early prediction of autoimmune (type 1) diabetes,” Diabetologia, 2017. View at Publisher · View at Google Scholar
  • Azza M. Kamel, Marwa F. Mira, Gamal T. A. Ebid, Samar H. Kassem, Eman R. Radwan, Mona Mamdouh, Maha Amin, Nora Badawy, Hafez Bazaraa, Amani Ibrahim, and Nermine Salah, “Association of insulin gene VNTR INS -23/Hph1 A>T (rs689) polymorphism with type 1 diabetes mellitus in Egyptian children,” Egyptian Journal of Medical Human Genetics, vol. 20, no. 1, 2019. View at Publisher · View at Google Scholar
  • Mette Korre Andersen, and Torben Hansen, “Genetic Aspects of Latent Autoimmune Diabetes in Adults: A Mini-Review,” Current Diabetes Reviews, vol. 15, no. 3, pp. 194–198, 2019. View at Publisher · View at Google Scholar