Anabela Ferro, Maria-José Castro, Carolina Lemos, Mónica Santos, Alda Sousa, José Pereira-Monteiro, Jorge Sequeiros, Patrícia Maciel, "The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal", Disease Markers, vol. 25, Article ID 178679, 7 pages, 2008. https://doi.org/10.1155/2008/178679
The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal
Migraine is a debilitating disorder affecting a large proportion of the population. The effect of methylenetrathydrofolate reductase (GeneID: 4524) polymorphisms in migraine etiology and development has been a theme of great interest. Several populations were evaluated with contradictory results. In this case-control study, we investigated the effect of the C677T polymorphism in MTHFR, as a genetic risk factor for migraine, in the Portuguese population. We observed that, overall, there was no significant difference in the frequencies of MTHFR C677T genotypes or of the T-allele among the Portuguese migraineurs when compared to controls. There was also no association of migraine with aura with MTHFR genotypes or with the T-allele, in contrast with previous studies. Regarding the risk of the T-allele homozygote carriers, there was an equal probability to develop migraine with aura over migraine without aura in our patients. Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population.
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