Disease Markers

Disease Markers / 2008 / Article

Open Access

Volume 25 |Article ID 178679 | https://doi.org/10.1155/2008/178679

Anabela Ferro, Maria-José Castro, Carolina Lemos, Mónica Santos, Alda Sousa, José Pereira-Monteiro, Jorge Sequeiros, Patrícia Maciel, "The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal", Disease Markers, vol. 25, Article ID 178679, 7 pages, 2008. https://doi.org/10.1155/2008/178679

The C677T Polymorphism in MTHFR Is Not Associated with Migraine in Portugal

Received08 Oct 2008
Accepted08 Oct 2008


Migraine is a debilitating disorder affecting a large proportion of the population. The effect of methylenetrathydrofolate reductase (GeneID: 4524) polymorphisms in migraine etiology and development has been a theme of great interest. Several populations were evaluated with contradictory results. In this case-control study, we investigated the effect of the C677T polymorphism in MTHFR, as a genetic risk factor for migraine, in the Portuguese population. We observed that, overall, there was no significant difference in the frequencies of MTHFR C677T genotypes or of the T-allele among the Portuguese migraineurs when compared to controls. There was also no association of migraine with aura with MTHFR genotypes or with the T-allele, in contrast with previous studies. Regarding the risk of the T-allele homozygote carriers, there was an equal probability to develop migraine with aura over migraine without aura in our patients. Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population.

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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