Disease Markers

Disease Markers / 2008 / Article

Open Access

Volume 24 |Article ID 784313 | https://doi.org/10.1155/2008/784313

Agnieszka Piwowar, Maria Knapik-Kordecka, Maria Warwas, "Ischemia-Modified albumin level in type 2 diabetes mellitus—Preliminary report", Disease Markers, vol. 24, Article ID 784313, 7 pages, 2008. https://doi.org/10.1155/2008/784313

Ischemia-Modified albumin level in type 2 diabetes mellitus—Preliminary report

Received23 Jul 2008
Accepted23 Jul 2008

Abstract

Aim: The main goal of the present study was the evaluation of ischemia-modified albumin (IMA) in patients with type 2 diabetes mellitus and estimation of its connection with vascular complications, glycemic control, hypertension, dyslipidemia and obesity.Methods: In 76 diabetic patients and 25 control subjects, a plasma level of IMA by manually performed, spectrophotometric Co(II)-albumin binding assay was determined. Other parameters such as glucose, fructosamine, HbA1c, total cholesterol and its fractions (HDL, LDL), triglicerydes were estimated by routine methods.Results: Diabetic patients had significantly higher level of IMA in comparison with control subjects. There were not significant differences between groups with various states of vascular complications although the lowest concentration of IMA was observed in patients with microangiopathy. Patients with poor glycemic control had higher IMA level in comparison with these with good glycemic control. Significant correlation was observed between IMA and HbA1c. Among the risk factors, only blood pressure and LDL showed a weak relationship with IMA level.Conclusions: Our results revealed, for the first time, higher level of IMA in diabetic patients which confirms that it may be of non-cardiac origin. We can suggest that the albumin molecule in plasma of diabetic patients is modified in the chronic hypoxia conditions provoked mainly by hyperglycemia and oxidative stress in diabetes.

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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